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<p>Improving treatment outcomes and survival rates depends on the successful and timely detection of cancer biomarkers. For this study, we have designed a multilayer sensor structure based on the Krestchmann–Raether sensor structure using Silver (Ag), Platinum diselenide (PtSe<sub>2</sub>), and Cerium Trifluoride (CeF<sub>3</sub>) layers to simulate a highly sensitive Surface Plasmon Resonance (SPR) sensor. The structure was modelled for its optical properties using the Transfer matrix technique (TMT) and angle interrogation technique. The sensitivity analysis was done for two targeted breast cancer cell lines (Type I &amp; II), known as MCF-7 and MDA-MB (MM-231). The sensitivity of 212.85 degree/RIU and 211.42 degree/RIU was achieved for Breast cancer Type II (MM-231) and Type I (MCF-7), respectively, and their respective figures of merits (FoM) of 24.2 RIU<sup>−1</sup> and 22.19 RIU<sup>−1</sup>. This paper presents the significance and novelty of this new-designed SPR structure for its applicability and sensitivity for practical uses in biomedical applications, including cancer diagnostics of the future.</p>

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Sensitivity enhancement of surface plasmon resonance sensor for cancerous cell detection for breast Type I and Type II using the Kretschmann–Raether structure

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Bhishma Karki,
  • Youssef Trabelsi,
  • Manoj Kumar,
  • Malatesh Akkur,
  • S. Emalda Roslin,
  • Basanta Kumar Panigrahi,
  • Amrindra Pal

摘要

Improving treatment outcomes and survival rates depends on the successful and timely detection of cancer biomarkers. For this study, we have designed a multilayer sensor structure based on the Krestchmann–Raether sensor structure using Silver (Ag), Platinum diselenide (PtSe2), and Cerium Trifluoride (CeF3) layers to simulate a highly sensitive Surface Plasmon Resonance (SPR) sensor. The structure was modelled for its optical properties using the Transfer matrix technique (TMT) and angle interrogation technique. The sensitivity analysis was done for two targeted breast cancer cell lines (Type I & II), known as MCF-7 and MDA-MB (MM-231). The sensitivity of 212.85 degree/RIU and 211.42 degree/RIU was achieved for Breast cancer Type II (MM-231) and Type I (MCF-7), respectively, and their respective figures of merits (FoM) of 24.2 RIU−1 and 22.19 RIU−1. This paper presents the significance and novelty of this new-designed SPR structure for its applicability and sensitivity for practical uses in biomedical applications, including cancer diagnostics of the future.