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<p>We present a comparative investigation of one-dimensional photonic crystal (1D PC) and quasi-periodic photonic crystal (1D QPC) structures—specifically Fibonacci and Thue-Morse sequences—for biosensing applications using various blood components as defect layers. The transmission spectra for platelets, plasma, white blood cells (WBC), and hemoglobin (HB) were investigated for both healthy and infected states. The study highlights a distinct resonance wavelength shift in each structure corresponding to changes in refractive index, enabling the detection of health conditions. Among the three configurations, the Fibonacci-based 1D QPC exhibited the best sensing performance, with the highest sensitivity and figure of merit (FOM). For instance, it achieved a FOM of 220.17 /RIU for platelets, 275.25 /RIU for plasma, 266.77 /RIU for WBCs, and 232.42 /RIU for HB—significantly outperforming in case of the Fibonacci sequence structure. The Thue-Morse structure showed moderate improvements over the periodic case, but the Fibonacci design delivered the sharpest resonance modes and clearest distinction between healthy and infected samples. These results demonstrate the potential of quasi-periodic Fibonacci photonic structures for highly sensitive, label-free biosensing applications in medical diagnostics.</p>

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Comparative analysis of periodic and quasi-periodic 1D photonic crystals for blood-based biosensing

  • 期刊论文

  • 发表日期：

    2026年1月9日

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  • Sumitra Dewal,
  • Bhuvneshwer Suthar,
  • Vijent Bhojak

摘要

We present a comparative investigation of one-dimensional photonic crystal (1D PC) and quasi-periodic photonic crystal (1D QPC) structures—specifically Fibonacci and Thue-Morse sequences—for biosensing applications using various blood components as defect layers. The transmission spectra for platelets, plasma, white blood cells (WBC), and hemoglobin (HB) were investigated for both healthy and infected states. The study highlights a distinct resonance wavelength shift in each structure corresponding to changes in refractive index, enabling the detection of health conditions. Among the three configurations, the Fibonacci-based 1D QPC exhibited the best sensing performance, with the highest sensitivity and figure of merit (FOM). For instance, it achieved a FOM of 220.17 /RIU for platelets, 275.25 /RIU for plasma, 266.77 /RIU for WBCs, and 232.42 /RIU for HB—significantly outperforming in case of the Fibonacci sequence structure. The Thue-Morse structure showed moderate improvements over the periodic case, but the Fibonacci design delivered the sharpest resonance modes and clearest distinction between healthy and infected samples. These results demonstrate the potential of quasi-periodic Fibonacci photonic structures for highly sensitive, label-free biosensing applications in medical diagnostics.