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<p>This study presents a real-time biosensor for hemoglobin concentration detection based on optical Tamm resonance in a one-dimensional photonic crystal platform. The sensor architecture, comprising a silver layer, a blood sample layer, and a periodic Si/SiO<sub>2</sub> multilayer on a BK7 glass substrate, supports sharp resonance features due to Tamm state excitation at the metal–dielectric interface. Notably, the biosensor differentiates blood groups (A, B, and O) through distinct resonance wavelength shifts arising from their characteristic refractive index differences, enabling group-specific hemoglobin detection. The resonance dip initially appears at 751.1&#xa0;nm and exhibits a pronounced redshift with increasing hemoglobin concentration, reaching up to 814.2&#xa0;nm for 200&#xa0;g/L in blood group O. Using the Transfer Matrix Method, the optical response is evaluated under both normal and oblique incidence for TE and TM polarizations. The biosensor demonstrates exceptional performance under TE-polarized oblique incidence, achieving a maximum sensitivity of 0.599&#xa0;nm/(g/L), a figure of merit of 0.716 1/(g/L), and a detection limit as low as 0.069&#xa0;g/L. The prism-free, planar configuration ensures a compact and cost-effective setup ideal for point-of-care diagnostics. Additionally, the device maintains high spectral resolution and stable operation across physiological temperature ranges, making it a robust platform for real-time clinical blood analysis.</p>

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Real-time hemoglobin detection across blood groups using tamm resonance biosensor

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Samad Roshan Entezar

摘要

This study presents a real-time biosensor for hemoglobin concentration detection based on optical Tamm resonance in a one-dimensional photonic crystal platform. The sensor architecture, comprising a silver layer, a blood sample layer, and a periodic Si/SiO2 multilayer on a BK7 glass substrate, supports sharp resonance features due to Tamm state excitation at the metal–dielectric interface. Notably, the biosensor differentiates blood groups (A, B, and O) through distinct resonance wavelength shifts arising from their characteristic refractive index differences, enabling group-specific hemoglobin detection. The resonance dip initially appears at 751.1 nm and exhibits a pronounced redshift with increasing hemoglobin concentration, reaching up to 814.2 nm for 200 g/L in blood group O. Using the Transfer Matrix Method, the optical response is evaluated under both normal and oblique incidence for TE and TM polarizations. The biosensor demonstrates exceptional performance under TE-polarized oblique incidence, achieving a maximum sensitivity of 0.599 nm/(g/L), a figure of merit of 0.716 1/(g/L), and a detection limit as low as 0.069 g/L. The prism-free, planar configuration ensures a compact and cost-effective setup ideal for point-of-care diagnostics. Additionally, the device maintains high spectral resolution and stable operation across physiological temperature ranges, making it a robust platform for real-time clinical blood analysis.