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<p>A high performance Kretschmann configuration-based surface plasmons resonance (SPR) biosensor is proposed for the detection of hepatocellular carcinoma (HCC) liver tissues. The proposed structure consists of calcium fluoride (CaF<sub>2</sub>) prism, silver (Ag) metal, and a heterojunction of titanium dioxide (TiO<sub>2</sub>), lead titanate (PbTiO<sub>3</sub>), and molybdenum di selenide (MoSe<sub>2</sub>). Role of constituents materials is analyzed in terms of their contribution towards enhancement in the performance. At near infrared wavelength of 1000&#xa0;nm, the thickness and number of layers of constituent layers is optimized in the light of practical realization. The proposed biosensor provides an ultrahigh sensitivity of 486&#xa0;deg/RIU with a full-width half maximum (FWHM) of 1.0720&#xa0;degrees and a figure of merits (FoM) of 453.35 RIU<sup>−1</sup>. Further, the corresponding power-loss ratio is also calculated. Hence, the combined performance factor for the proposed sensor is 480.56 RIU<sup>−1</sup>. The novelty of the work relies in the design and selection of material (especially TiO<sub>2</sub> and PbTiO<sub>3</sub>) that offers the highest possible values of performance parameters for prism based sensor in the best of our knowledge.</p>

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TiO2 and PbTiO3 assisted SPR biosensor for detection of malignancy in human-liver tissue with high sensitivity and figure of merit

  • 期刊论文

  • 发表日期：

    2025年1月13日

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  • Laxmi Jaiswal,
  • Adarsh Chandra Mishra,
  • Sapana Yadav,
  • Pooja Lohia,
  • D. K. Dwivedi,
  • R. K. Yadav,
  • Upendra Kulshrestha,
  • Ammar M. Tighezza,
  • M. Khalid Hossain

摘要

A high performance Kretschmann configuration-based surface plasmons resonance (SPR) biosensor is proposed for the detection of hepatocellular carcinoma (HCC) liver tissues. The proposed structure consists of calcium fluoride (CaF2) prism, silver (Ag) metal, and a heterojunction of titanium dioxide (TiO2), lead titanate (PbTiO3), and molybdenum di selenide (MoSe2). Role of constituents materials is analyzed in terms of their contribution towards enhancement in the performance. At near infrared wavelength of 1000 nm, the thickness and number of layers of constituent layers is optimized in the light of practical realization. The proposed biosensor provides an ultrahigh sensitivity of 486 deg/RIU with a full-width half maximum (FWHM) of 1.0720 degrees and a figure of merits (FoM) of 453.35 RIU−1. Further, the corresponding power-loss ratio is also calculated. Hence, the combined performance factor for the proposed sensor is 480.56 RIU−1. The novelty of the work relies in the design and selection of material (especially TiO2 and PbTiO3) that offers the highest possible values of performance parameters for prism based sensor in the best of our knowledge.