Scholarlink

<p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), the dominant internal RNA modification in eukaryotic mRNA, plays an important regulatory role in female reproductive physiology and associated pathologies. This review systematically outlines the precise regulatory mechanisms exerted by m<sup>6</sup>A writers, erasers, and readers in core processes including germ cell development, early embryogenesis, and hormone signaling. We further elaborate on how aberrant m<sup>6</sup>A modifications contribute to the pathogenesis of various female reproductive disorders, such as gynecological cancer, polycystic ovary syndrome, and preeclampsia. In addition, we conducted a rigorous assessment of the therapeutic and diagnostic potential targeting the m<sup>6</sup>A mechanism. By synthesizing mechanistic insights from both neoplastic and non-neoplastic diseases, this review provides a comprehensive framework for understanding the epitranscriptomic governance of female reproductive health and proposes new directions for future research and clinical translation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Emerging roles of m6A in female reproductive disorders: from molecular mechanisms to therapeutic targets

  • 期刊论文

  • 发表日期：

    2026年7月17日

查看全文
  • Ruimin Yuan,
  • Yuqi He,
  • Tao Qian,
  • Mingyu Huang,
  • Jia Li,
  • Chi Huang,
  • Qingqing Gu,
  • Shuangyan Zhang,
  • Mao Zhu,
  • Xiuyan Wei,
  • Xuanyu Li,
  • Siqi Luo,
  • Xuan Zhu,
  • Zhongyu Han,
  • Lan Yuan

摘要

N6-methyladenosine (m6A), the dominant internal RNA modification in eukaryotic mRNA, plays an important regulatory role in female reproductive physiology and associated pathologies. This review systematically outlines the precise regulatory mechanisms exerted by m6A writers, erasers, and readers in core processes including germ cell development, early embryogenesis, and hormone signaling. We further elaborate on how aberrant m6A modifications contribute to the pathogenesis of various female reproductive disorders, such as gynecological cancer, polycystic ovary syndrome, and preeclampsia. In addition, we conducted a rigorous assessment of the therapeutic and diagnostic potential targeting the m6A mechanism. By synthesizing mechanistic insights from both neoplastic and non-neoplastic diseases, this review provides a comprehensive framework for understanding the epitranscriptomic governance of female reproductive health and proposes new directions for future research and clinical translation.