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Background <p>Platelet-rich plasma (PRP) is increasingly used for refractory thin endometrium and recurrent implantation failure, yet its histological effects remain poorly characterized. We report a case of longstanding infertility in which intrauterine PRP was administered during a frozen embryo transfer cycle that was subsequently cancelled, permitting pathological evaluation.</p> Methods <p>Clinical history, ultrasound findings, treatment cycles, and endometrial responses were reviewed. A pre‑PRP endometrial specimen was obtained during endometrial polyp removal, and a post‑PRP specimen was collected following an endometrial scratch. Biopsies before and after PRP were evaluated for histopathological features, including neovascularization, stromal remodeling, and immune cell infiltration. Ultrasound parameters, particularly endometrial thickness and a triple-line pattern, were compared with those from a prior PRP cycle.</p> Results <p>After PRP treatment, endometrial thickness went from 8.60 to 9.15&#xa0;mm without a triple-line pattern. Histology showed a weakly proliferative endometrium with no evidence of enhanced vascularity, inflammatory infiltration, or structural remodeling. Findings were unchanged compared with the endometrium without PRP exposure. Overall, no discernible tissue-level changes were identified following PRP.</p> Conclusions <p>In this case, intrauterine PRP was not associated with detectable histological alterations. These findings suggest a potential disconnect between ultrasound‑measured endometrial thickness and underlying tissue response. Further mechanistic studies are warranted.</p>

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Intrauterine platelet-rich plasma and subsequent endometrial pathology evaluation in a patient undergoing a frozen embryo transfer cycle: a case report

  • 期刊论文

  • 发表日期：

    2026年4月25日

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  • Shu Qin Wei,
  • Michael H. Dahan,
  • Lili Fu,
  • Hillian Yan,
  • Seang Lin Tan

摘要

Background

Platelet-rich plasma (PRP) is increasingly used for refractory thin endometrium and recurrent implantation failure, yet its histological effects remain poorly characterized. We report a case of longstanding infertility in which intrauterine PRP was administered during a frozen embryo transfer cycle that was subsequently cancelled, permitting pathological evaluation.

Methods

Clinical history, ultrasound findings, treatment cycles, and endometrial responses were reviewed. A pre‑PRP endometrial specimen was obtained during endometrial polyp removal, and a post‑PRP specimen was collected following an endometrial scratch. Biopsies before and after PRP were evaluated for histopathological features, including neovascularization, stromal remodeling, and immune cell infiltration. Ultrasound parameters, particularly endometrial thickness and a triple-line pattern, were compared with those from a prior PRP cycle.

Results

After PRP treatment, endometrial thickness went from 8.60 to 9.15 mm without a triple-line pattern. Histology showed a weakly proliferative endometrium with no evidence of enhanced vascularity, inflammatory infiltration, or structural remodeling. Findings were unchanged compared with the endometrium without PRP exposure. Overall, no discernible tissue-level changes were identified following PRP.

Conclusions

In this case, intrauterine PRP was not associated with detectable histological alterations. These findings suggest a potential disconnect between ultrasound‑measured endometrial thickness and underlying tissue response. Further mechanistic studies are warranted.