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Purpose <p>Assisted reproductive technology (ART) has been associated with increased risks of congenital anomalies and preterm birth. However, its role in influencing the complexity of specific malformations, such as esophageal atresia (EA), remains unclear. This study aimed to assess whether ART impacts the phenotypic complexity of EA, including associated anomalies and VACTERL (vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies) association.</p> Methods <p>Data from 374 EA patients enrolled in the European Pediatric Surgeons’ Association (EUPSA) Esophageal Atresia Registry were analyzed. Patients were grouped based on mode of conception (28 ART and 346 natural conception) and compared for demographics, gestational age, birth weight, associated malformations, VACTERL association, and genetic disorders.</p> Results <p>Gestational age and birth weight were comparable between groups (36.5 ± 3.3 vs. 36.4 ± 3.3&#xa0;weeks, <i>p</i> = 0.42; 2412.3 ± 761.6&#xa0;g vs. 2601.3 ± 744.3&#xa0;g, <i>p</i> = 0.24). Maternal age was significantly higher in the ART group. The prevalence of cardiac, gastrointestinal, renal, musculoskeletal, and vertebral anomalies did not differ significantly. All cardiac anomalies in ART patients were minor. VACTERL association rates (25.0% vs. 18.5%, <i>p</i> = 0.398) and genetic disorder prevalence (7.1% vs. 4.9%, <i>p</i> = 0.605) were comparable.</p> Conclusions <p>ART does not appear to increase the complexity of EA in terms of associated malformations, VACTERL spectrum disorders, or genetic abnormalities. Further studies with larger cohorts and detailed ART subtype data are warranted to confirm these findings.</p>

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Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?

  • 期刊论文

  • 发表日期：

    2025年9月11日

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  • Federica Pederiva,
  • Nigel Hall,
  • Tuktu Soyer,
  • Francesco Morini,
  • Sanja Sindjic-Antunovic,
  • Mohit Kakar,
  • Andrea Conforti,
  • Pietro Bagolan,
  • Helen Engstrand Lilja,
  • Henrik Ehren,
  • Udo Rolle,
  • Zoran Radojicic,
  • Marija Lukac,
  • Matthijs Oomen,
  • Pier Giorgio Gamba,
  • Francesco Fascetti Leon,
  • Ivo de Blaauw,
  • Horst Scharbatke,
  • Rene Wijnen,
  • Holger Till,
  • Florian Friedmacher,
  • Lubomir Bockanic,
  • Michel Gocik,
  • Sergey V. Minaev,
  • Liviu Muntean,
  • Aurel Mironescu,
  • Risto Rintala,
  • Hussein Khairy,
  • Mahmoud ElFiky,
  • Giovanna Riccipetitoni,
  • Sara Costanzo,
  • Pierluigi Lelli Chiesa,
  • Gabriele Lisi,
  • Juan A. Tovar,
  • Leopoldo Martinez,
  • Alessio Pini Prato,
  • Germana Casaccia,
  • Benno Ure,
  • Joachim Kuebler,
  • Natalia Newland,
  • Michal Rygl

摘要

Purpose

Assisted reproductive technology (ART) has been associated with increased risks of congenital anomalies and preterm birth. However, its role in influencing the complexity of specific malformations, such as esophageal atresia (EA), remains unclear. This study aimed to assess whether ART impacts the phenotypic complexity of EA, including associated anomalies and VACTERL (vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies) association.

Methods

Data from 374 EA patients enrolled in the European Pediatric Surgeons’ Association (EUPSA) Esophageal Atresia Registry were analyzed. Patients were grouped based on mode of conception (28 ART and 346 natural conception) and compared for demographics, gestational age, birth weight, associated malformations, VACTERL association, and genetic disorders.

Results

Gestational age and birth weight were comparable between groups (36.5 ± 3.3 vs. 36.4 ± 3.3 weeks, p = 0.42; 2412.3 ± 761.6 g vs. 2601.3 ± 744.3 g, p = 0.24). Maternal age was significantly higher in the ART group. The prevalence of cardiac, gastrointestinal, renal, musculoskeletal, and vertebral anomalies did not differ significantly. All cardiac anomalies in ART patients were minor. VACTERL association rates (25.0% vs. 18.5%, p = 0.398) and genetic disorder prevalence (7.1% vs. 4.9%, p = 0.605) were comparable.

Conclusions

ART does not appear to increase the complexity of EA in terms of associated malformations, VACTERL spectrum disorders, or genetic abnormalities. Further studies with larger cohorts and detailed ART subtype data are warranted to confirm these findings.