Purpose <p>This study aims to summarize and analyze the existing research on anxiety and depression within the field of assisted reproduction technology, exploring current hotspots, emerging frontiers, and trends, while offering insights for future research directions.</p> Methods <p>Relevant literature on anxiety and depression among assisted reproduction patients was retrieved from the Web of Science Core Collection up to December 31, 2023. The analysis, encompassing studies, countries, authors, institutions, keywords, and co-citation networks, was visualized using VOSviewer version 1.6.19 and the “bibliometrix” R package version 4.3.1.</p> Results <p>A total of 1458 studies were included in the analysis. The literature on anxiety and depression in assisted reproduction patients has shown a fluctuating upward trend. <i>Human Reproduction</i> was identified as the leading journal, with the highest citations across multiple journals. Boivin J emerged as the most prolific author, with Cardiff University contributing the most publications. The USA and China led in terms of both publications and citations. Highly cited studies were predominantly published between 1995 and 2007, with half of the included studies published before 2000. Key research hotspots included evidence synthesis, acupuncture treatment for infertility, and the mental health of patients undergoing assisted reproductive technology, particularly focusing on anxiety and depression.</p> Conclusion <p>As awareness of psychological health in assisted reproductive technology continues to grow, future research should focus on mitigating anxiety and depression to enhance patient outcomes and patient quality of life. Integrating psychological support and monitoring long-term psychological outcomes are crucial for optimizing assisted reproductive technology success and fostering holistic, patient-centered care.</p>