Scholarlink

Background <p>This study aimed to investigate the optimal follicular diameter at the initiation of luteal-phase ovarian stimulation (LPOS) protocol after natural ovulation to achieve better laboratory outcomes.</p> Methods <p>This retrospective cohort study analyzed 286 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles in patients who began the LPOS protocol after natural ovulation. Patients were categorized into three groups based on follicle diameter at initiation: small diameter follicles (SDF, &lt; 5&#xa0;mm, <i>n</i> = 74), medium diameter follicles (MDF, 5.0–7.9&#xa0;mm, <i>n</i> = 140), and large diameter follicles (LDF, ≥ 8&#xa0;mm, <i>n</i> = 72). Linear regression analysis was used to assess the relationship between initial follicle diameter and laboratory outcomes.</p> Result <p>Significant differences were noted in anti-Müllerian hormone (AMH), body mass index (BMI), and initial gonadotropin (Gn) dose among the groups. Primary outcomes included oocyte retrieval rate (SDF vs. MDF vs. LDF: 0.92 ± 0.88 vs. 0.68 ± 0.48 vs. 0.58 ± 0.54, <i>p</i> = 0.004), mature oocyte retrieval rate (0.78 ± 0.74 vs. 0.58 ± 0.43 vs. 0.51 ± 0.50, <i>p</i> = 0.01), and 2PN rate (0.58 ± 0.68 vs. 0.44 ± 0.40 vs. 0.36 ± 0.43, <i>p</i> = 0.03) in the SDF group were significantly higher than those in the MDF and LDF groups. Multivariate regression analysis, adjusting for potential confounders such as age, AMH levels, baseline follicle-stimulating hormone (FSH) levels, BMI, and initial Gn dosage, revealed negative correlations between the initial follicle diameter and oocyte retrieval rate (<i>p</i> = 0.02), mature oocyte retrieval rate (<i>p</i> = 0.02), and 2PN rate (<i>p</i> = 0.04).</p> Conclusions <p>Oocyte retrieval rate, mature oocyte retrieval rate, and 2PN rate decreased significantly with increasing follicle diameter at the initiation of LPOS. The optimal laboratory outcome was achieved with an initial follicle diameter of less than 5&#xa0;mm.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Smaller follicle diameter improves outcomes in natural LPOS: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年2月11日

查看全文
  • Jifan Tan,
  • Sirui Liao,
  • Dehai Gan,
  • Guoqing Fan,
  • Yanwen Xu,
  • Jia Huang,
  • Yuan Yuan

摘要

Background

This study aimed to investigate the optimal follicular diameter at the initiation of luteal-phase ovarian stimulation (LPOS) protocol after natural ovulation to achieve better laboratory outcomes.

Methods

This retrospective cohort study analyzed 286 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles in patients who began the LPOS protocol after natural ovulation. Patients were categorized into three groups based on follicle diameter at initiation: small diameter follicles (SDF, < 5 mm, n = 74), medium diameter follicles (MDF, 5.0–7.9 mm, n = 140), and large diameter follicles (LDF, ≥ 8 mm, n = 72). Linear regression analysis was used to assess the relationship between initial follicle diameter and laboratory outcomes.

Result

Significant differences were noted in anti-Müllerian hormone (AMH), body mass index (BMI), and initial gonadotropin (Gn) dose among the groups. Primary outcomes included oocyte retrieval rate (SDF vs. MDF vs. LDF: 0.92 ± 0.88 vs. 0.68 ± 0.48 vs. 0.58 ± 0.54, p = 0.004), mature oocyte retrieval rate (0.78 ± 0.74 vs. 0.58 ± 0.43 vs. 0.51 ± 0.50, p = 0.01), and 2PN rate (0.58 ± 0.68 vs. 0.44 ± 0.40 vs. 0.36 ± 0.43, p = 0.03) in the SDF group were significantly higher than those in the MDF and LDF groups. Multivariate regression analysis, adjusting for potential confounders such as age, AMH levels, baseline follicle-stimulating hormone (FSH) levels, BMI, and initial Gn dosage, revealed negative correlations between the initial follicle diameter and oocyte retrieval rate (p = 0.02), mature oocyte retrieval rate (p = 0.02), and 2PN rate (p = 0.04).

Conclusions

Oocyte retrieval rate, mature oocyte retrieval rate, and 2PN rate decreased significantly with increasing follicle diameter at the initiation of LPOS. The optimal laboratory outcome was achieved with an initial follicle diameter of less than 5 mm.