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<p>The hydrothermal synthesis of biocompatible, fluorescent boron-nitride nanoparticles (BNNPs) was performed. The BNNPs accumulated in C6 rat glioma cells and were visualized upon irradiation at 365 nm. The efficiency of BNNP internalization by cells was found to depend on the incubation time and medium parameters. BNNPs at concentrations up to 1 mg/mL were promising for use in bioimaging and boron neutron capture therapy because they had no cytotoxic effect on the cells.</p>

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Accumulation and Visualization of Boron-nitride Nanoparticles in Glioma Cells

  • 期刊论文

  • 发表日期：

    2026年7月6日

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  • A. V. Bahdanava,
  • E. I. Venskaya,
  • L. M. Lukyanenko,
  • E. V. Shamova,
  • T. A. Kulahava

摘要

The hydrothermal synthesis of biocompatible, fluorescent boron-nitride nanoparticles (BNNPs) was performed. The BNNPs accumulated in C6 rat glioma cells and were visualized upon irradiation at 365 nm. The efficiency of BNNP internalization by cells was found to depend on the incubation time and medium parameters. BNNPs at concentrations up to 1 mg/mL were promising for use in bioimaging and boron neutron capture therapy because they had no cytotoxic effect on the cells.