Spectrophotometric Survey of Cefixime Via Facile Complexation with Vanadyl Sulfate

Herein, an accurate and simple spectrophotometric method for investigating cefixime in different formulations is reported. The proposed method elaborates on the complexation of cefixime with vanadyl sulfate in acidic media. The yellow color complexation product manifested its maximum absorbance peak at around 321 nm, and obeyed Beer's law in 2 × 10⁻⁶–1 × 10⁻⁴ M cefixime concentration. Obtained spectroscopic data were used to calculate standard deviation (S), limit of detection (LOD), limit of quantification (LOQ), and relative standard deviation (RSD) as 6.5 × 10⁻⁵, 1.96 × 10⁻⁴, 6.5 × 10⁻⁴ M, and 0.057%, respectively. In addition, the formation constant associated with the complex obtained, calculated as 5.7 × 1016, indicates that the final complex was remarkably stable.