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<p>Inappropriate antibiotic use in broiler farming drives antibiotic resistance and residues in poultry, raising significant public health concerns that require safe and effective alternatives. This study investigated the effects of <i>Limnospira platensis</i> polysaccharide and biomass supplementation in drinking water, compared to a tylosin-trimethoprim-sulfadiazine (TTS) antibiotic on broiler growth, biochemical profiles, cecal microbiota, and organ histomorphology. For 42-days, 360 one-day-old male Cobb 500 broiler chicks were randomly assigned to six treatment groups, each with six replicates of ten chicks. Treatments included a control group (CON) with unsupplemented drinking water; an antibiotic group (ATB) supplemented with 1&#xa0;g L<sup>−1</sup> tylosin-trimethoprim-sulfadiazine (TTS) antibiotic; two <i>L. platensis</i> polysaccharide groups (SPS1 and SPS2) receiving 0.5&#xa0;g L<sup>−1</sup> and 1&#xa0;g L<sup>−1</sup>; and two <i>L. platensis</i> dry biomass groups (SPO1 and SPO2) receiving 2.5&#xa0;g L<sup>−1</sup> and 5&#xa0;g L<sup>−1</sup>. The results indicated that supplementing drinking water with 5&#xa0;g L<sup>−1</sup> <i>L. platensis</i> dry biomass (SPO2) significantly improved body weight, feed intake, and the European broiler index compared to the control, antibiotic, and other <i>L. platensis</i> treatments (p &lt; 0.05). This treatment also significantly lowered serum creatinine, triglycerides, LDL-cholesterol, and AST activity. <i>L. platensis</i> and antibiotic treatments significantly reduced cecal coliform, enterobacteria, and staphylococci populations. <i>Limnospira platensis</i> dry biomass and polysaccharide supplementation preserved liver and spleen structure and significantly increased economic efficiency, outperforming control and antibiotic groups (p &lt; 0.05). These findings suggest that 5&#xa0;g L<sup>−1</sup> <i>L. platensis</i> dry biomass in drinking water represents a promising and effective alternative to antibiotics for improving broiler chicken growth performance, health, and economic efficiency.</p>

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Assessment of Limnospira platensis (Spirulina platensis) biomass and polysaccharide as sustainable alternatives to antibiotics in broiler production: Impacts on growth, physiological health, cecal microbiota, and economic efficiency

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Pierre Fils Rodrigue Magwell,
  • Oscar Wamba Fotsop,
  • Emile Minyaka,
  • Frederic Marie Tavea,
  • Appolin Medueghue Fofou,
  • Amandine Plidikoua,
  • Loick Pradel Kojom Foko,
  • Leopold Gustave Lehman

摘要

Inappropriate antibiotic use in broiler farming drives antibiotic resistance and residues in poultry, raising significant public health concerns that require safe and effective alternatives. This study investigated the effects of Limnospira platensis polysaccharide and biomass supplementation in drinking water, compared to a tylosin-trimethoprim-sulfadiazine (TTS) antibiotic on broiler growth, biochemical profiles, cecal microbiota, and organ histomorphology. For 42-days, 360 one-day-old male Cobb 500 broiler chicks were randomly assigned to six treatment groups, each with six replicates of ten chicks. Treatments included a control group (CON) with unsupplemented drinking water; an antibiotic group (ATB) supplemented with 1 g L−1 tylosin-trimethoprim-sulfadiazine (TTS) antibiotic; two L. platensis polysaccharide groups (SPS1 and SPS2) receiving 0.5 g L−1 and 1 g L−1; and two L. platensis dry biomass groups (SPO1 and SPO2) receiving 2.5 g L−1 and 5 g L−1. The results indicated that supplementing drinking water with 5 g L−1 L. platensis dry biomass (SPO2) significantly improved body weight, feed intake, and the European broiler index compared to the control, antibiotic, and other L. platensis treatments (p < 0.05). This treatment also significantly lowered serum creatinine, triglycerides, LDL-cholesterol, and AST activity. L. platensis and antibiotic treatments significantly reduced cecal coliform, enterobacteria, and staphylococci populations. Limnospira platensis dry biomass and polysaccharide supplementation preserved liver and spleen structure and significantly increased economic efficiency, outperforming control and antibiotic groups (p < 0.05). These findings suggest that 5 g L−1 L. platensis dry biomass in drinking water represents a promising and effective alternative to antibiotics for improving broiler chicken growth performance, health, and economic efficiency.