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<p>Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. CVDs are triggered by thrombosis, which occurs when a clot forms inside a blood vessel due to increased platelet activity. Antiplatelet drugs are widely used for the prevention and treatment of CVDs; however, various side effects have been reported. Several foods (or their bioactive components) have demonstrated effectiveness in reducing platelet activation, suggesting potential benefits in lowering the risk of thrombosis. This has led to a growing interest in discovering new natural sources of antiplatelet compounds. Cyanobacteria represent a promising source of bioactive molecules with antiplatelet properties, including the water-soluble phycobilin pigment phycocyanin. In this research, we evaluated the effects of aqueous extracts from nine strains of cyanobacteria on platelet aggregation and activation. Eight strains exhibited significant antiplatelet activity, with CCM-UdeC-089 (Aff. <i>Anabaena iyengarii</i>) being the most promising. No correlation was found between the antiplatelet activity of the extracts and their phycocyanin content, indicating that other metabolites within the extracts, and/or their synergistic effects, may account for their bioactivity. Since cyanobacteria are fast-growing cultivable resources, their production as a new source of potent natural antiplatelet compounds presents a promising opportunity for the nutraceutical and pharmaceutical markets interested in preventing and treating CVDs.</p>

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Screening cyanobacteria with antiplatelet properties as potential sources of natural products for preventing and treating cardiovascular diseases

  • 期刊论文

  • 发表日期：

    2025年11月7日

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  • Patricia I. Gómez,
  • David Flaig,
  • Edwards Araya,
  • Olivia Rosales,
  • Javiera Acuña,
  • Marcelo Alarcón

摘要

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. CVDs are triggered by thrombosis, which occurs when a clot forms inside a blood vessel due to increased platelet activity. Antiplatelet drugs are widely used for the prevention and treatment of CVDs; however, various side effects have been reported. Several foods (or their bioactive components) have demonstrated effectiveness in reducing platelet activation, suggesting potential benefits in lowering the risk of thrombosis. This has led to a growing interest in discovering new natural sources of antiplatelet compounds. Cyanobacteria represent a promising source of bioactive molecules with antiplatelet properties, including the water-soluble phycobilin pigment phycocyanin. In this research, we evaluated the effects of aqueous extracts from nine strains of cyanobacteria on platelet aggregation and activation. Eight strains exhibited significant antiplatelet activity, with CCM-UdeC-089 (Aff. Anabaena iyengarii) being the most promising. No correlation was found between the antiplatelet activity of the extracts and their phycocyanin content, indicating that other metabolites within the extracts, and/or their synergistic effects, may account for their bioactivity. Since cyanobacteria are fast-growing cultivable resources, their production as a new source of potent natural antiplatelet compounds presents a promising opportunity for the nutraceutical and pharmaceutical markets interested in preventing and treating CVDs.