Purpose <p>To assess the prevalence and trends of developmental disabilities among U.S. children and adolescents aged 3–17 years from 2016 to 2024.</p> Methods <p>Using data from the National Health Interview Survey (NHIS, 2021–2024) and the National Survey of Children’s Health (NSCH, 2016–2023). Only NHIS contributed 2024 data, with NSCH through 2023. We calculated the weighted prevalence with 95% confidence intervals for attention-deficit/hyperactivity disorder, learning disability, autism spectrum disorder, intellectual disability, and other developmental delays and examined trends from 2016 to 2024.</p> Results <p>Prevalence increased significantly for attention-deficit/hyperactivity disorder, learning disability, and autism spectrum disorder but remained stable for intellectual disability and other developmental delays. Age-specific analyses revealed distinct distributions: attention-deficit/hyperactivity disorder, learning disability were most common in school-age children, whereas autism spectrum disorder was higher among preschool-aged children compared with older groups.</p> Conclusion <p>The prevalence of developmental disabilities among U.S. children has risen substantially. This persistent upward trend underscores a growing public health challenge, necessitating enhanced early identification, service delivery, and research into the multifactorial drivers behind these increases.</p>