Purpose <p>This study aimed to evaluate the prevalence and determinants of quality of life (QoL) among caregivers of children facing mental health challenges. Specifically, it explored how caregivers’ sociodemographic characteristics influence their QoL.</p> Methods <p>A cross-sectional design was employed, with data collected at the Psychology Outpatient Department of a rehabilitation institute in Islamabad. Between October 2022 and February 2023, a total of 350 mothers of children with mental health issues participated. Data were gathered using an interview-based questionnaire, which included information on caregivers’ and children’s demographics, disability-related factors, and the PedsQL Family Impact Module (FIM) to assess QoL.</p> Results <p>Findings indicated that certain sociodemographic variables significantly impacted caregivers’ QoL. Older age of both caregivers and children, as well as a higher number of children, were negatively associated with QoL. In contrast, higher monthly household income was positively linked to better caregiver well-being. Interestingly, caregivers of boys with disabilities reported a higher QoL compared to those caring for girls with disabilities. Additionally, family structure played a role: caregivers living in nuclear families experienced better QoL compared to those in joint family systems.</p> Conclusion <p>These results highlight the complex interplay between social, economic, and familial factors in shaping the caregiving experience. Understanding these relationships is essential for developing targeted interventions and support systems to enhance the well-being of caregivers managing the mental health needs of their children.</p>