A monomial ideal \(I\subseteq \mathbb {K}[x_1,\ldots , x_n]\) is called a Simis ideal if \(I^{(s)}=I^s\) for all \(s\ge 1\) , where \(I^{(s)}\) denotes the s-th symbolic power of I. Let I be a support-2 monomial ideal such that its irreducible primary decomposition is minimal. We prove that I is a Simis ideal if and only if \(\sqrt{I}\) is Simis and I has a standard linear weighting. This result thereby proves a recent conjecture for the class of support-2 monomial ideals proposed by Mendez, Pinto, and Villarreal. Furthermore, we give a complete characterization of the Cohen-Macaulay property for support-2 monomial ideals whose radical is the edge ideal of a whiskered graph. Finally, we classify when these ideals are Simis in degree 2.