Let \(S_1\) and \(S_2\) be completely 0-simple semigroups. We provide a necessary and sufficient condition for the power digraph of \(S_1\) to be isomorphic to a Cayley graph of \(S_2\) . Moreover, we characterize a completely 0-simple semigroup whose power digraph can be represented as a Cayley graph of some completely 0-simple semigroup and describe a completely 0-simple semigroup some of whose Cayley graphs are isomorphic to the power digraph of some completely 0-simple semigroup.