<p>The advancement of nuclear science and technology has resulted in the generation of increasing amounts of nuclear waste containing uranium, which poses severe risks to human health and the environment due to its high toxicity, radioactivity, and prolonged half-life. Effective remediation strategies are essential to mitigate these risks. This study presents a novel electrochemical approach for the remediation of uranium (VI) ions from aqueous media, utilizing nano zero-valent iron particles (nZVIs) incorporated onto a boron-doped diamond (BDD) electrode. The BDD electrode was modified with nZVIs prepared as an ink, and a 2.0 mM uranyl acetate dihydrate (UO₂(C₂H₃O₂)₂·2H₂O) solution in 0.10 M KClO₄ served as the uranium (VI) source. Chronoamperometry was employed at a potential of -0.800 V vs. reversible hydrogen electrode for 40 min to facilitate the electrodeposition-based remediation of uranyl ions (UO₂²⁺). Comparative analysis was conducted using an unmodified BDD electrode to evaluate the remediation performance. Results revealed that the nZVIs/BDD system achieved a significantly higher removal of uranium (0.104 mg) compared to the unmodified BDD electrode (5.13 × 10⁻³&#xa0;mg). Advanced characterization techniques, including cyclic voltammetry, scanning electron microscopy, and energy-dispersive X-ray fluorescence spectroscopy, confirmed uranium deposition, the formation of a thin layer on the nZVIs/BDD assembly, and the emergence of 3D structures on the unmodified BDD electrode. Raman spectroscopy identified the formation of different uranium oxides, UO₂, UO₃, and U₃O₈, on the nZVIs/BDD film surface and the unmodified BDD electrode during the electrochemical remediation process. These findings highlight the enhanced efficiency and efficacy of uranium (VI) electrochemical remediation facilitated by the nZVIs-modified BDD electrode.</p> Graphical abstract <p></p>