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Purpose <p>To assess efficacy of 0.1% sodium hyaluronate on femtosecond laser scanning during small incision lenticule extraction (SMILE).</p> Methods <p>A prospective randomized clinical trial was conducted involving 100 patients (200 eyes) who were prepared to undergo binocular SMILE. The two eyes of each participant were randomly assigned to either the 0.1% sodium hyaluronate eye drop group (HA group) or the no 0.1% sodium hyaluronate eye drop group (NHA group). Prior to the laser scan of SMILE, the HA&#xa0;group received an application of 0.1% sodium hyaluronate to the eye immediately. The NHA group did not receive 0.1% sodium hyaluronate. The number of intraoperative cases of black area and opaque bubble layer (OBL) and the lenticule separation time were recorded. Then, the Strehl Ratio (SR) was used to evaluate postoperative optical quality.</p> Results <p>The incidence of OBL and black area in HA&#xa0;group and NHA&#xa0;group was no statistical significance. The lenticule separation time of the HA&#xa0;group was significantly shorter than that of the NHA&#xa0;group (<i>Z</i> =  − 5.940, <i>P</i> &lt; 0.01). The SR values of the HA&#xa0;group and the NHA&#xa0;group were as following 0.3608 (0.2879, 0.4359) and 0.3079 (0.2537, 0.3820) one month after SMILE, with significant difference between the two groups (<i>Z</i> =  − 3.163, <i>P</i> &lt; 0.01). No additional complications were reported in any of the patients.</p> Conclusions <p>The immediate application of 0.1% sodium hyaluronate during femtosecond laser scanning in SMILE may contribute to more favorable conditions for femtosecond laser scanning, facilitate lenticule separation, and is associated with better postoperative optical quality, as indicated by higher SR values at one month.</p>

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Effect of 0.1% sodium hyaluronate on femtosecond laser scanning during small incision lenticule extraction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月14日

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  • Yu Shuai,
  • Xi Liu,
  • Tao Zeng,
  • Kun Chen

摘要

Purpose

To assess efficacy of 0.1% sodium hyaluronate on femtosecond laser scanning during small incision lenticule extraction (SMILE).

Methods

A prospective randomized clinical trial was conducted involving 100 patients (200 eyes) who were prepared to undergo binocular SMILE. The two eyes of each participant were randomly assigned to either the 0.1% sodium hyaluronate eye drop group (HA group) or the no 0.1% sodium hyaluronate eye drop group (NHA group). Prior to the laser scan of SMILE, the HA group received an application of 0.1% sodium hyaluronate to the eye immediately. The NHA group did not receive 0.1% sodium hyaluronate. The number of intraoperative cases of black area and opaque bubble layer (OBL) and the lenticule separation time were recorded. Then, the Strehl Ratio (SR) was used to evaluate postoperative optical quality.

Results

The incidence of OBL and black area in HA group and NHA group was no statistical significance. The lenticule separation time of the HA group was significantly shorter than that of the NHA group (Z =  − 5.940, P < 0.01). The SR values of the HA group and the NHA group were as following 0.3608 (0.2879, 0.4359) and 0.3079 (0.2537, 0.3820) one month after SMILE, with significant difference between the two groups (Z =  − 3.163, P < 0.01). No additional complications were reported in any of the patients.

Conclusions

The immediate application of 0.1% sodium hyaluronate during femtosecond laser scanning in SMILE may contribute to more favorable conditions for femtosecond laser scanning, facilitate lenticule separation, and is associated with better postoperative optical quality, as indicated by higher SR values at one month.