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Purpose <p>To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora.</p> Material and methods <p>Demographic characteristics, follow-up period, nasolacrimal passage patency, degree of punctum stenosis (graded between 0 and 5), presence of epiphora and accompanying diseases of the cases who applied with epiphora complaint between June 2015 and May 2024 were evaluated retrospectively. 3 snip punctoplasty was applied to all cases.The cases were divided into 3 groups. Group 1: 3 snip without MMC, group 2: 3 snip with 0.3% MMC for 1&#xa0;min, group 3: 3 snip with 0.3% MMC for 2&#xa0;min.</p> Results <p>In this study, 180 eyes of a total of 90 cases were examined. 50 (55.5%) of the cases were female and 40 (44.5%) were male. The average age of the cases was 42.2 ± 3.8 (35–68).The average follow-up period was 6.2 ± 1.5 (6–8) months. In 2 of the cases (2.2%), the postoperative nasolacrimal lavage was closed at the punctum level. Preoperative punctal stenosis grade was 2 in 60 cases (66.6%) and 1 in 30 cases (33.4%). There were no postoperative epiphora complaints in 24 (80%) patients in group 1, 27 (90%) patients in group 2, and 28 (93.3%) patients in group 3. The difference between groups 1 and 2 was statistically significant (<i>p</i> &lt; 0.05).The difference between groups 2 and 3 was not statistically significant (<i>p</i> &gt; 0.05). Postoperative corneal epithelial defect development was observed in 1 of the cases.</p> Conclusions <p>3 snip surgery is a successful method in the treatment of punctal stenosis, and the use of MMC may increase success. Increasing the duration of MMC application did not improve surgical success.</p>

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The effect of mitomycin-C on 3 snip punctoplasty

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Betül Dertsiz Kozan,
  • Bahadır Utlu

摘要

Purpose

To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora.

Material and methods

Demographic characteristics, follow-up period, nasolacrimal passage patency, degree of punctum stenosis (graded between 0 and 5), presence of epiphora and accompanying diseases of the cases who applied with epiphora complaint between June 2015 and May 2024 were evaluated retrospectively. 3 snip punctoplasty was applied to all cases.The cases were divided into 3 groups. Group 1: 3 snip without MMC, group 2: 3 snip with 0.3% MMC for 1 min, group 3: 3 snip with 0.3% MMC for 2 min.

Results

In this study, 180 eyes of a total of 90 cases were examined. 50 (55.5%) of the cases were female and 40 (44.5%) were male. The average age of the cases was 42.2 ± 3.8 (35–68).The average follow-up period was 6.2 ± 1.5 (6–8) months. In 2 of the cases (2.2%), the postoperative nasolacrimal lavage was closed at the punctum level. Preoperative punctal stenosis grade was 2 in 60 cases (66.6%) and 1 in 30 cases (33.4%). There were no postoperative epiphora complaints in 24 (80%) patients in group 1, 27 (90%) patients in group 2, and 28 (93.3%) patients in group 3. The difference between groups 1 and 2 was statistically significant (p < 0.05).The difference between groups 2 and 3 was not statistically significant (p > 0.05). Postoperative corneal epithelial defect development was observed in 1 of the cases.

Conclusions

3 snip surgery is a successful method in the treatment of punctal stenosis, and the use of MMC may increase success. Increasing the duration of MMC application did not improve surgical success.