Scholarlink

Purpose <p>To evaluate choroidal thickness (CT) and choroidal vascularity index (CVI) in patients with primary Sjögren’s syndrome (pSS), and to compare these parameters with healthy controls.</p> Methods <p>This study included 35 pSS patients and 37 healthy controls. CVI measurements were performed using enhanced depth imaging optical coherence tomography (EDI-OCT). The peripapillary nasal (PPN) and temporal (PPT) regions, with a width of 1000&#xa0;µm, were analyzed, along with subfoveal (SF) areas at 500, 1000, and 1500&#xa0;µm. The EDI-OCT images were transferred to ImageJ software for image binarization and CVI calculation. Subfoveal choroidal thickness (SFCT) was also measured.</p> Results <p>There was no statistical difference in age, gender and BMI distribution between the groups (all <i>p</i> &gt; 0.05). All CVI values at 5 different measurement points ​​(SF 500&#xa0;µm, SF 1000&#xa0;µm, SF 1500&#xa0;µm, PPN and PPT) were significantly lower in the pSS group (<i>p</i> = 0.01, <i>p</i> = 0.07, <i>p</i> = 0.017, <i>p</i> = 0.03 and <i>p</i> = 0.019, respectively). SFCT values ​​were found to be significantly lower in the patient group (326.2 ± 89.4&#xa0;µm vs 380.6 ± 78.2&#xa0;µm, <i>p</i> = 0.008). A significant positive correlation was found between SFCT measurements and PPN CVI and PPT CVI values (r = 0.515, <i>p</i> = 0.002; r = 0.493, <i>p</i> = 0.003, respectively).</p> Conclusion <p>We detected significantly thinned CT and decreased CVI values ​​in patients with pSS, for the first time. As a result of our study, CT and CVI measurements may become parameters that can be used in the follow-up of pSS patients in whom no pathology is detected in routine eye examination and perhaps in the evaluation of treatment response.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of choroidal vascularity index and choroidal thickness in patients with primary Sjögren’s syndrome

  • 期刊论文

  • 发表日期：

    2025年10月29日

查看全文
  • Cem Ozisler,
  • Yasemin Ozdamar Erol,
  • Gulnur Celik Yilmaz,
  • Taha Salim Cevik,
  • Sevinc Can Sandikci,
  • Ayse Bahar Kelesoglu Dincer,
  • Melih Pamukcu,
  • Hakan Apaydin,
  • Emine Gozde Aydemir Guloksuz,
  • Zuhal Ozisler

摘要

Purpose

To evaluate choroidal thickness (CT) and choroidal vascularity index (CVI) in patients with primary Sjögren’s syndrome (pSS), and to compare these parameters with healthy controls.

Methods

This study included 35 pSS patients and 37 healthy controls. CVI measurements were performed using enhanced depth imaging optical coherence tomography (EDI-OCT). The peripapillary nasal (PPN) and temporal (PPT) regions, with a width of 1000 µm, were analyzed, along with subfoveal (SF) areas at 500, 1000, and 1500 µm. The EDI-OCT images were transferred to ImageJ software for image binarization and CVI calculation. Subfoveal choroidal thickness (SFCT) was also measured.

Results

There was no statistical difference in age, gender and BMI distribution between the groups (all p > 0.05). All CVI values at 5 different measurement points ​​(SF 500 µm, SF 1000 µm, SF 1500 µm, PPN and PPT) were significantly lower in the pSS group (p = 0.01, p = 0.07, p = 0.017, p = 0.03 and p = 0.019, respectively). SFCT values ​​were found to be significantly lower in the patient group (326.2 ± 89.4 µm vs 380.6 ± 78.2 µm, p = 0.008). A significant positive correlation was found between SFCT measurements and PPN CVI and PPT CVI values (r = 0.515, p = 0.002; r = 0.493, p = 0.003, respectively).

Conclusion

We detected significantly thinned CT and decreased CVI values ​​in patients with pSS, for the first time. As a result of our study, CT and CVI measurements may become parameters that can be used in the follow-up of pSS patients in whom no pathology is detected in routine eye examination and perhaps in the evaluation of treatment response.