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Objective <p>This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.</p> Methods <p>Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.</p> Results <p>BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (<i>p</i> &lt; 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (<i>p</i> &lt; 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = − 0.758, <i>p</i> = 0.001).</p> Conclusions <p>This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.</p>

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Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study

  • 期刊论文

  • 发表日期：

    2025年9月27日

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  • Alba Chiara Termite,
  • Pasquale Viggiano,
  • Giacomo Boscia,
  • Lorenzo Accurso Tagano,
  • Marta Zerbinati,
  • Tommaso Festa,
  • Giulia Fracchiolla,
  • Antonio Fracchiolla,
  • Ermete Giancipoli,
  • Iaculli Cristiana,
  • Francesco Pignatelli,
  • Maria Grazia Pignataro,
  • Federico Moscara,
  • Pasquale Puzo,
  • Nicola Recchimurzo,
  • Giovanni Alessio,
  • Francesco Boscia

摘要

Objective

This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.

Methods

Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.

Results

BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = − 0.758, p = 0.001).

Conclusions

This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.