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Purpose <p>To investigate the relationship between type 2 diabetes and changes of the lid margin, meibomian glands and tear film in dry eye patients, to explore the possible pathological mechanism of the effect of type 2 diabetes on the ocular surface of dry eye disease.</p> Research design and methods <p>This cross-sectional study included 302 eyes of 151 patients. Participants were divided into two groups: dry eye disease with type 2 diabetes group (DED-DM group, n = 108) and dry eye disease without diabetes group (DED group, n = 194). All patients underwent morphological and physiological functional evaluation of the ocular surface and a blood glucose level test.</p> Results <p>Compared with the DED group, the DED-DM group had higher upper lid margin irregularity(<i>P</i> = 0.035), lid margin vascularity(<i>P</i> &lt; 0.0001), plugging of gland orifices grade(<i>P</i> &lt; 0.0001), lid margin thickening grade(upper, <i>P</i> &lt; 0.001; lower, <i>P</i> = 0.002), upper meibomian gland dropout(<i>P</i> = 0.003) and ciliary hyperemia(<i>P</i> = 0.013), and shorter first non-invasive tear breakup time(NIBUT) (<i>P</i> = 0.011). Blood glucose level had a significant correlation with NIBUT(first, <i>P</i> = 0.006; average, <i>P</i> = 0.003), lid margin thickening grade(upper, <i>P</i> = 0.006; lower,<i> P</i> = 0.001), and lower lid margin irregularity (<i>P</i> = 0.016).</p> Conclusions <p>In patients with type 2 diabetes and dry eye, lid margin abnormalities, orifice plugging and tear film instability was more severe than patients with dry eye only.</p>

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Relationship between type 2 diabetes mellitus and changes of the lid margin, meibomian gland and tear film in dry eye patients: a cross-sectional study

  • 期刊论文

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  • 发表日期：

    2025年6月24日

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  • Yiran Hao,
  • Binge Wu,
  • Jun Feng,
  • Jing He,
  • Yunxiao Zang,
  • Lei Tian,
  • Ying Jie

摘要

Purpose

To investigate the relationship between type 2 diabetes and changes of the lid margin, meibomian glands and tear film in dry eye patients, to explore the possible pathological mechanism of the effect of type 2 diabetes on the ocular surface of dry eye disease.

Research design and methods

This cross-sectional study included 302 eyes of 151 patients. Participants were divided into two groups: dry eye disease with type 2 diabetes group (DED-DM group, n = 108) and dry eye disease without diabetes group (DED group, n = 194). All patients underwent morphological and physiological functional evaluation of the ocular surface and a blood glucose level test.

Results

Compared with the DED group, the DED-DM group had higher upper lid margin irregularity(P = 0.035), lid margin vascularity(P < 0.0001), plugging of gland orifices grade(P < 0.0001), lid margin thickening grade(upper, P < 0.001; lower, P = 0.002), upper meibomian gland dropout(P = 0.003) and ciliary hyperemia(P = 0.013), and shorter first non-invasive tear breakup time(NIBUT) (P = 0.011). Blood glucose level had a significant correlation with NIBUT(first, P = 0.006; average, P = 0.003), lid margin thickening grade(upper, P = 0.006; lower, P = 0.001), and lower lid margin irregularity (P = 0.016).

Conclusions

In patients with type 2 diabetes and dry eye, lid margin abnormalities, orifice plugging and tear film instability was more severe than patients with dry eye only.