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Introduction <p>The aim of this study was to investigate the fundus fluorescein angiography (FFA) findings in eyes initially diagnosed with idiopathic epiretinal membrane (iERM) and assess their impact on best-corrected visual acuity (BCVA).</p> Methods <p>This retrospective comparative study included 136 patients (151 eyes) diagnosed with iERM and a control group of 121 healthy fellow eyes. All patients underwent FFA and optical coherence tomography (OCT). The primary outcomes summarized the characteristics of FFA and OCT in patients with iERM, and analyzed the relationship between FFA findings and visual acuity.</p> Results <p>Vascular leakage (<i>P</i> = 0.009) were significantly more prevalent in eyes with iERM compared to controls. Multivariate logistic regression analysis indicated that optic disc hyperfluorescence (OR 4.05; 95% CI 1.79–9.17; <i>P</i> = 0.001) were more likely to present in eyes with iERM. A lower OCT stage, fovea-recognizable, cellophane macular reflex type were associated with better BCVA.</p> Conclusion <p>Optic disc hyperfluorescence is independent risk factors of iERM. Howerer, these abnormalities do not show a significant association with visual function. The precise etiology remains to be fully elucidated.</p>

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Fundus fluorescein angiography findings in eyes initially diagnosed with idiopathic epiretinal membrane

  • 期刊论文

  • 发表日期：

    2025年5月9日

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  • Chen Chen,
  • Qi Zhang,
  • Linrui Li,
  • Xiaoyan Ding,
  • Lin Lu,
  • Xiujuan Zhao

摘要

Introduction

The aim of this study was to investigate the fundus fluorescein angiography (FFA) findings in eyes initially diagnosed with idiopathic epiretinal membrane (iERM) and assess their impact on best-corrected visual acuity (BCVA).

Methods

This retrospective comparative study included 136 patients (151 eyes) diagnosed with iERM and a control group of 121 healthy fellow eyes. All patients underwent FFA and optical coherence tomography (OCT). The primary outcomes summarized the characteristics of FFA and OCT in patients with iERM, and analyzed the relationship between FFA findings and visual acuity.

Results

Vascular leakage (P = 0.009) were significantly more prevalent in eyes with iERM compared to controls. Multivariate logistic regression analysis indicated that optic disc hyperfluorescence (OR 4.05; 95% CI 1.79–9.17; P = 0.001) were more likely to present in eyes with iERM. A lower OCT stage, fovea-recognizable, cellophane macular reflex type were associated with better BCVA.

Conclusion

Optic disc hyperfluorescence is independent risk factors of iERM. Howerer, these abnormalities do not show a significant association with visual function. The precise etiology remains to be fully elucidated.