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Purpose <p>To compare the efficacy and side-effect profile of interferon alpha-2b<b> (</b>IFNα2B) and topical 5-fluorouracil (5-FU) as primary treatment modalities for ocular surface squamous neoplasia (OSSN).</p> Methods <p>Retrospective comparative study of 116 OSSN eyes treated with topical 1 MIU IFNα2B with/without 5 MIU/cc subconjunctival injection (group 1) or topical 1% 5-FU (group 2) in mutually exclusive time periods of treatment.</p> Results <p>Of the 116 eyes with OSSN, 64 eyes belonged to group 1 and 52 eyes to group 2. The mean tumor basal conjunctival diameter for groups 1 and 2 was 10&#xa0;mm (median, 10&#xa0;mm; range 0–28&#xa0;mm) and 5&#xa0;mm (median, 4&#xa0;mm; range, 0–24&#xa0;mm) respectively (<i>p</i> &lt; 0.0001). Complete tumor regression with medical management alone was achieved in 51 (80%) eyes in group 1 and 43 (83%) eyes in group 2 (<i>p</i> = 0.6814). The mean number of sessions/cycles of treatment for complete tumor regression was 3 (median, 3; range, 1–6) for group 1 versus 2 (median, 2; range, 1–6) for group 2 (<i>p</i> &lt; 0.0001). Tumor recurrence was noted in 3 (5%) eyes in group 1 over a mean follow-up period (months) of 11 (median, 7; range, 3–41) versus 1 (2%) in group 2 (<i>p</i> = 0.25) over a mean follow-up period (months) of 6 (median, 5; range, 1–25). Side-effects included transient conjunctival hyperemia (9%), and flu-like symptoms (3%) in group 1 versus transient conjunctival hyperemia (2%), punctal stenosis (2%), and partial limbal stem cell deficiency (2%) in group 2.</p> Conclusion <p>Primary treatment of OSSN with IFNα2b or 5-FU offers comparable and good tumor control with minimal side-effects.</p>

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Interferon alpha-2b versus 5-fluorouracil as primary treatment modalities for ocular surface squamous neoplasia: a study of 116 eyes

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  • 发表日期：

    2025年3月12日

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  • Komal Bakal,
  • Adit Gupta,
  • Swathi Kaliki

摘要

Purpose

To compare the efficacy and side-effect profile of interferon alpha-2b (IFNα2B) and topical 5-fluorouracil (5-FU) as primary treatment modalities for ocular surface squamous neoplasia (OSSN).

Methods

Retrospective comparative study of 116 OSSN eyes treated with topical 1 MIU IFNα2B with/without 5 MIU/cc subconjunctival injection (group 1) or topical 1% 5-FU (group 2) in mutually exclusive time periods of treatment.

Results

Of the 116 eyes with OSSN, 64 eyes belonged to group 1 and 52 eyes to group 2. The mean tumor basal conjunctival diameter for groups 1 and 2 was 10 mm (median, 10 mm; range 0–28 mm) and 5 mm (median, 4 mm; range, 0–24 mm) respectively (p < 0.0001). Complete tumor regression with medical management alone was achieved in 51 (80%) eyes in group 1 and 43 (83%) eyes in group 2 (p = 0.6814). The mean number of sessions/cycles of treatment for complete tumor regression was 3 (median, 3; range, 1–6) for group 1 versus 2 (median, 2; range, 1–6) for group 2 (p < 0.0001). Tumor recurrence was noted in 3 (5%) eyes in group 1 over a mean follow-up period (months) of 11 (median, 7; range, 3–41) versus 1 (2%) in group 2 (p = 0.25) over a mean follow-up period (months) of 6 (median, 5; range, 1–25). Side-effects included transient conjunctival hyperemia (9%), and flu-like symptoms (3%) in group 1 versus transient conjunctival hyperemia (2%), punctal stenosis (2%), and partial limbal stem cell deficiency (2%) in group 2.

Conclusion

Primary treatment of OSSN with IFNα2b or 5-FU offers comparable and good tumor control with minimal side-effects.