Review on classification of polypoidal choroidal vasculopathy

Polypoidal choroidal vasculopathy (PCV) is a complex vascular disorder characterized by a branching neovascular network with polypoidal lesions at its termini. Despite extensive research, the etiology and pathogenesis of PCV remain inadequately understood, and the condition exhibits significant clinical and pathological heterogeneity. In recent years, numerous studies have identified potential subtypes within PCV and proposed various classification schemes. However, a universally accepted classification system for PCV has yet to be established.

This review aims to provide a comprehensive overview of the different classification methods for PCV that have emerged alongside advancements in imaging technologies and a deeper understanding of PCV, highlighting their clinical relevance and prognostic implications.

A systematic search of PubMed, Embase, Web of Science, and Cochrane databases was conducted. Literature management was facilitated using EndNote X9 software.

By synthesizing existing classification approaches, this paper seeks to offer a clearer understanding of PCV subtypes, which may guide future research and inform treatment strategies.