<p>This study introduces a novel multi-objective optimization framework (DBNO) that integrates deep Bayesian networks with a hybrid algorithm combining random search and innovation diffusion to address high-dimensional patent layout optimization challenges. The framework was developed in response to the increasing complexity of patent layout decisions, where traditional single-objective optimization methods prove inadequate for simultaneously addressing multiple conflicting objectives such as profit, risk, and sustainability. To evaluate the framework's effectiveness, we conducted comprehensive experiments comparing DBNO against established algorithms including genetic algorithm (GA), particle swarm optimization (PSO), and traditional Bayesian optimization methods. Performance metrics encompassed convergence speed, computational efficiency, optimization stability, and solution quality across multiple objectives. The results demonstrate that DBNO consistently outperforms benchmark algorithms, particularly in optimizing sustainability objectives. Notably, DBNO exhibited superior stability and higher success rates in the optimization process compared to GA and PSO, highlighting its robustness in handling complex high-dimensional optimization problems. Furthermore, the integration of innovation diffusion mechanisms significantly enhanced both the efficiency and accuracy of the optimization process. The primary contribution of this research lies in the novel combination of deep Bayesian networks with ensemble random search techniques, resulting in a powerful multi-objective optimization framework. This approach provides an effective solution for high-dimensional patent layout problems while offering new perspectives for patent strategic decision-making. The findings advance the field of multi-objective optimization and establish a foundation for future research in patent portfolio optimization.</p>