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Objective <p>To evaluate the clinical efficacy and safety of krill oil supplementation in patients with knee osteoarthritis (KOA) through a systematic review and meta-analysis. Potential mechanisms are discussed based on existing literature.</p> Methods <p>A systematic search was performed across PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) investigating krill oil supplementation in patients with KOA. Studies were selected according to pre-defined inclusion and exclusion criteria. Data were independently extracted by two reviewers and pooled using RevMan 5.4. Risk of bias was assessed with the Cochrane Risk of Bias tool.</p> Results <p>Six RCTs with 971 participants were included. Krill oil supplementation significantly improved pain and physical function (WOMAC scores at week 4), with moderate effects observed on stiffness. Krill oil significantly increased HDL-C and omega-3 levels, but had no effect on LDL-C and CRP. No significant adverse events were reported.</p> Conclusion <p>Krill oil is a promising functional food with a favorable safety profile for KOA symptom management, particularly for pain and physical function. The findings suggest potential mechanisms related to its anti-inflammatory and antioxidant effects, supporting its role in nutraceutical interventions for KOA.</p>

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Clinical efficacy and mechanisms of krill oil supplementation in knee osteoarthritis: meta-analysis and mechanistic insights

  • 期刊论文

  • 发表日期：

    2026年4月22日

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  • Haiyang Kou,
  • Huaiquan Liu,
  • Lingyan Lai,
  • Shili Yang,
  • Xinyan Zhang,
  • Yu Sun,
  • Yunling Xu,
  • Bo Chen

摘要

Objective

To evaluate the clinical efficacy and safety of krill oil supplementation in patients with knee osteoarthritis (KOA) through a systematic review and meta-analysis. Potential mechanisms are discussed based on existing literature.

Methods

A systematic search was performed across PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) investigating krill oil supplementation in patients with KOA. Studies were selected according to pre-defined inclusion and exclusion criteria. Data were independently extracted by two reviewers and pooled using RevMan 5.4. Risk of bias was assessed with the Cochrane Risk of Bias tool.

Results

Six RCTs with 971 participants were included. Krill oil supplementation significantly improved pain and physical function (WOMAC scores at week 4), with moderate effects observed on stiffness. Krill oil significantly increased HDL-C and omega-3 levels, but had no effect on LDL-C and CRP. No significant adverse events were reported.

Conclusion

Krill oil is a promising functional food with a favorable safety profile for KOA symptom management, particularly for pain and physical function. The findings suggest potential mechanisms related to its anti-inflammatory and antioxidant effects, supporting its role in nutraceutical interventions for KOA.