<p>Gamma-oryzanol, a potent nutraceutical derived from <i>Oryza sativa</i> and primarily extracted as rice bran oil, has gained significant interest due to its antioxidant, anti-inflammatory, and neurorestorative properties. This review explores its potential as a promising alternative for managing neuropathic pain, especially considering the limitations and adverse effects associated with conventional pharmacological treatments. A comprehensive literature search was conducted using databases such as PubMed, ScienceDirect, Google Scholar, Taylor and Francis, and Scopus, focusing on studies published from 2010 onward. These studies highlighted gamma-oryzanol’s multifaceted pharmacodynamic actions that target the complex mechanisms underlying neuropathic pain. Its natural origin and favourable safety profile further support its potential as a phytotherapeutic agent. In the evolving field of phyto-based neuroprotective therapies, gamma-oryzanol represents a compelling intersection between pharmacology and nutrition. Preclinical and clinical studies evaluating γ-oryzanol’s effects on neuropathic-pain-related mechanisms were systematically reviewed. Nonetheless, to fully realise its therapeutic potential, further translational research and clinical trials are essential.</p> Graphical abstract <p></p>