<p>Ischemic stroke is among the leading causes of death and long-term disability worldwide. Significant advancements in anti-ischemic therapy have been developed in the last few decades. Nonetheless, ischemic stroke continues to pose a significant problem, with candidate medications typically failing to provide favorable clinical outcomes throughout preclinical phase testing. Rutin, a natural flavonoid, has shown preventive properties against ischemic stroke through several mechanisms, such as antioxidant, anti-apoptotic, neuroprotective, and anti-neuroinflammatory. However, further research is required to understand how rutin protects against stroke. In addition, studies on the reports on human subjects ought to be carried out.</p> Graphical abstract <p>Rutin reduced oxidative stress, neuroinflammation, and apoptosis in ischemic stroke, although the protective role of rutin in excitotoxicity in ischemic stroke needs to be evaluated in future studies.</p> <p></p>