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<p><i>Veitchia arecina</i> Becc. (Arecaceae family), a palm species known for its antioxidant and anti-inflammatory properties, attributed to bioactive constituents that may facilitate wound healing and enhance dermatological health. However, the wound-healing efficacy of <i>Veitchia arecina</i> remains uninvestigated. This study is the first to evaluate the chemical composition, antioxidant and anti-inflammatory activities, dermal safety, and wound-healing potential of <i>Veitchia arecina</i> leaf fractions in a rat model. The study aimed to elucidate their mechanism of action in tissue regeneration. The chemical composition of light petroleum ether and <i>n-</i>butanol soluble fractions of <i>Veitchia arecina</i> was analyzed via gas–liquid chromatography–mass spectrometry (GLC-MS) and liquid chromatography–electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS), respectively. In-vitro antioxidant (DPPH), anti-inflammatory (COX-1), and MTT assays were performed utilizing a 5% gel formulation, with povidone-iodine serving as the standard. The phytochemical analysis of the tested fractions using GLC-MS and LC–ESI–MS/MS revealed the presence of sterols, terpenes, vitamin E isomers, and fatty acids in light petroleum ether soluble fraction as well as flavonoid glycosides and phenolics in <i>n-</i>butanol soluble fraction. Both fractions showed significant antioxidant and COX-1 inhibitory activities comparable to Trolox and ibuprofen. The topical gel formulations exhibited no dermal toxicity while improving healing by attenuating inflammation and oxidative stress, enhancing blood vessel formation, re-epithelization, formation of collagen, and restoring skin architecture. Notably, the <i>n</i>-butanol fraction demonstrated superior efficacy in facilitating granulation tissue maturation. This study demonstrates the dermal safety, antioxidant, anti-inflammatory, and wound-healing properties of <i>Veitchia arecina</i> leaf fractions, particularly flavonoid-rich variants, suggesting their potential therapeutic applications in dermatological conditions.</p>

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RETRACTED ARTICLE: Phytochemical studies of Veitchia arecina Becc. leaves with evaluation of in-vitro, in-vivo anti-inflammatory, and wound healing properties in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月9日

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  • Radwa S. Emad,
  • Rasha A. Attia,
  • Mona Fekry,
  • Nesreen M. I. M. Elkomy,
  • Tarek M. Ibrahim,
  • Amal A. Al-Gendy

摘要

Veitchia arecina Becc. (Arecaceae family), a palm species known for its antioxidant and anti-inflammatory properties, attributed to bioactive constituents that may facilitate wound healing and enhance dermatological health. However, the wound-healing efficacy of Veitchia arecina remains uninvestigated. This study is the first to evaluate the chemical composition, antioxidant and anti-inflammatory activities, dermal safety, and wound-healing potential of Veitchia arecina leaf fractions in a rat model. The study aimed to elucidate their mechanism of action in tissue regeneration. The chemical composition of light petroleum ether and n-butanol soluble fractions of Veitchia arecina was analyzed via gas–liquid chromatography–mass spectrometry (GLC-MS) and liquid chromatography–electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS), respectively. In-vitro antioxidant (DPPH), anti-inflammatory (COX-1), and MTT assays were performed utilizing a 5% gel formulation, with povidone-iodine serving as the standard. The phytochemical analysis of the tested fractions using GLC-MS and LC–ESI–MS/MS revealed the presence of sterols, terpenes, vitamin E isomers, and fatty acids in light petroleum ether soluble fraction as well as flavonoid glycosides and phenolics in n-butanol soluble fraction. Both fractions showed significant antioxidant and COX-1 inhibitory activities comparable to Trolox and ibuprofen. The topical gel formulations exhibited no dermal toxicity while improving healing by attenuating inflammation and oxidative stress, enhancing blood vessel formation, re-epithelization, formation of collagen, and restoring skin architecture. Notably, the n-butanol fraction demonstrated superior efficacy in facilitating granulation tissue maturation. This study demonstrates the dermal safety, antioxidant, anti-inflammatory, and wound-healing properties of Veitchia arecina leaf fractions, particularly flavonoid-rich variants, suggesting their potential therapeutic applications in dermatological conditions.