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Objective <p>This study aims to investigate the impact of full-spectrum <i>Cannabis sativa</i> extract (FSC) treatment on gut and peripheral organ protection after ischemic stroke.</p> Main methods <p>Male Wistar rats were subjected to 60-min middle cerebral artery occlusion (MCAO) or sham surgery, and received FSC (15 or 30&#xa0;mg/kg) or coconut oil by gavage at different time points post-MCAO. After 72&#xa0;h, neurological score, infarct volume, blood cell count, thymus, spleen and adrenal gland size and weight, serum corticosterone, intestinal permeability, oxidative stress, and inflammatory cytokines in peripheral organs were assessed.</p> Key findings <p>The results show a significant improvement in neurological deficits, suggesting the therapeutic potential of FSC in post-stroke recovery. Additionally, a reduction in body mass, a decrease in blood cells related to the immune response, and atrophy of lymphoid organs, lower corticosterone levels, and reduced intestinal permeability were observed. FSC treatment also demonstrated a crucial role in protecting against oxidative stress and post-stroke lung inflammation.</p> Significance <p>The discovery of the positive impacts of FSC in this study represents an entry point for new explorations and perspectives within this field. With latent potential, these findings have the power to shape clinical research, especially in the realm of neurodegenerative diseases and innovative therapies. Therefore, the results highlight the promising role of FSC, paving the way for more effective and transformative clinical interventions.</p>

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Full-spectrum Cannabis sativa extract enhances gut-peripheral organ integrity after experimental ischemic stroke

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Solange de Souza Stork,
  • Khiany Mathias,
  • Fernanda Gava,
  • Larissa Joaquim,
  • David dos Santos,
  • Anita Dal Bó Tiscoski,
  • Sandra Bonfante,
  • Yasmin Ribeiro Strickert,
  • Richard Simon Machado,
  • Helena Mafra Martins,
  • Jéssica Schaefer Chaves,
  • Jaqueline Generoso,
  • Lucineia Gainski Danielski,
  • Amanda Della Giustina,
  • Rahisa Scussel,
  • Rafael Bitencourt,
  • Josiel Mileno Mack,
  • Mariana Pereira de Souza Goldim,
  • Ricardo Andrez Machado-de-Ávila,
  • Tatiana Barichello,
  • Franciane Bobinski,
  • Fabricia Petronilho

摘要

Objective

This study aims to investigate the impact of full-spectrum Cannabis sativa extract (FSC) treatment on gut and peripheral organ protection after ischemic stroke.

Main methods

Male Wistar rats were subjected to 60-min middle cerebral artery occlusion (MCAO) or sham surgery, and received FSC (15 or 30 mg/kg) or coconut oil by gavage at different time points post-MCAO. After 72 h, neurological score, infarct volume, blood cell count, thymus, spleen and adrenal gland size and weight, serum corticosterone, intestinal permeability, oxidative stress, and inflammatory cytokines in peripheral organs were assessed.

Key findings

The results show a significant improvement in neurological deficits, suggesting the therapeutic potential of FSC in post-stroke recovery. Additionally, a reduction in body mass, a decrease in blood cells related to the immune response, and atrophy of lymphoid organs, lower corticosterone levels, and reduced intestinal permeability were observed. FSC treatment also demonstrated a crucial role in protecting against oxidative stress and post-stroke lung inflammation.

Significance

The discovery of the positive impacts of FSC in this study represents an entry point for new explorations and perspectives within this field. With latent potential, these findings have the power to shape clinical research, especially in the realm of neurodegenerative diseases and innovative therapies. Therefore, the results highlight the promising role of FSC, paving the way for more effective and transformative clinical interventions.