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Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review

  • Mahmood Jawad,
  • Subasini Uthirapathy,
  • Farag M. A. Altalbawy,
  • Enwa Felix Oghenemaro,
  • Jasur Rizaev,
  • Madan Lal,
  • Mamdouh Eldesoqui,
  • Naveen Sharma,
  • Atreyi Pramanik,
  • Ahmed Khudhair AL-Hamairy

摘要

Alzheimer’s disease is a devastating neurodegenerative disorder that affects millions of people worldwide. One of the key pathological features of Alzheimer’s disease is oxidative stress, which is characterized by an imbalance between the production of reactive oxygen species and the body’s ability to neutralize them with antioxidants. In recent years, there has been growing interest in the potential role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease. This review paper aims to provide a comprehensive overview of the current research on antioxidant supplementation in Alzheimer’s disease and its effects on oxidative stress markers. The paper will examine the underlying mechanisms of oxidative stress in Alzheimer’s disease, the potential benefits of antioxidant supplementation, and the challenges and limitations of using antioxidants as a therapeutic strategy.