Scholarlink

Background <p>Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose–response meta-analysis of randomized controlled trials (RCTs) evaluated the effects of whey protein (WP), casein protein (CP), or MP supplementation on serum levels of cytokines and adipokines in adults.</p> Methods <p>A comprehensive search of various online databases was conducted to find appropriate clinical trials published until September 2024. A random-effect statistical model was implemented.</p> Results <p>The meta-analysis included 53 RCTs. It was indicated that MP supplements had no substantial effects on serum values of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin. However, there were statistically significant decreases in serum levels of interleukin-6 (IL-6) following supplementation with MP (weighted mean difference (WMD): −&#xa0;0.25&#xa0;pg/mL, 95% CI −&#xa0;0.48, −&#xa0;0.03; P = 0.026) in the intervention group compared with the control group.</p> Conclusion <p>This study revealed that MP supplementation may not have any considerable impacts on the levels of cytokines and adipokines.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年1月7日

查看全文
  • Shooka Mohammadi,
  • Damoon Ashtary-Larky,
  • Milad Mehrbod,
  • Narges Kouhi Sough,
  • Hossein Salehi Omran,
  • Sina Dolatshahi,
  • Niusha Amirani,
  • Omid Asbaghi

摘要

Background

Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose–response meta-analysis of randomized controlled trials (RCTs) evaluated the effects of whey protein (WP), casein protein (CP), or MP supplementation on serum levels of cytokines and adipokines in adults.

Methods

A comprehensive search of various online databases was conducted to find appropriate clinical trials published until September 2024. A random-effect statistical model was implemented.

Results

The meta-analysis included 53 RCTs. It was indicated that MP supplements had no substantial effects on serum values of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin. However, there were statistically significant decreases in serum levels of interleukin-6 (IL-6) following supplementation with MP (weighted mean difference (WMD): − 0.25 pg/mL, 95% CI − 0.48, − 0.03; P = 0.026) in the intervention group compared with the control group.

Conclusion

This study revealed that MP supplementation may not have any considerable impacts on the levels of cytokines and adipokines.