<p>Owing to its affordability and superior mechanical properties, natural fiber-reinforced composite (NFRC) is rapidly being utilized across several industrial applications, such as packaging, construction materials, and automotive sectors. This study examines the influence of Boron carbide (B₄C) and Titanium oxide (TiO₂) filler content on the mechanical and wear performance of Canna indica/curaua fiber reinforced hybrid composites. In comparison to TiO₂, B₄C filler was more efficacious in enhancing the tensile strength of composites. The tensile strength of the unfilled composite was enhanced by 8.63% and 13.15% with the incorporation of 2% B₄C and 3% TiO₂, respectively. Increasing the load reduced the coefficient of friction (COF) but elevated the wear rate and mass loss for both neat and hybrid composites, as indicated by wear studies conducted under diverse conditions. Composites infused with B₄C exhibited the lowest coefficients of friction (COF). Composites infused with TiO₂ and B₄C exhibited less matrix deformation, pitting, and porosity compared to unmodified composites. The incorporation of TiO₂ and B₄C fillers improved impact resistance. Hybrid composites containing 3wt% B₄C exhibited an improvement in impact strength from 5.5 to 10.7&#xa0;J/m². The ANN model effectively estimated the COF and wear rate values, as the experimental results closely aligned with the predicted values.</p>