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<p>The amalgamation of poly (lactic acid) (PLA) with (PEO) poly (ethylene oxide) improves hydrophilicity and tensile strength of nanofibers, rendering appropriate for biomedical uses such as dressings. This research investigates influence of electrospinning parameters—flow rate, needle-to-collector distance and applied voltage—on the properties of PEO/PLA nanofibers, optimizing through Taguchi methodology to improve their surface and mechanical characteristics for clinical applications. Due to significant expenses and duration involved in doing comprehensive experimental tests, ANN- model were created to anticipate test results efficiently, hence expediting the discovery of design. ANOVA indicates flow rate is primary factor of fiber diameter. Ideal electrospinning setup produces nanofibers with average diameter of 132.26 ± 11.23&#xa0;nm. Fibers display remarkable flexibility, tensile strength, and contact angle of 37°, indicating enhanced hydrophilicity that facilitates proliferation and cell adhesion—crucial elements at advancing wound healing. The optimized scaffold substantially surpasses alternative, 1.1&#xa0;ml/h flow rate, 22&#xa0;kV applied voltage, and 18&#xa0;cm needle-to-collector distance, exhibit larger diameters, decreased hydrophilicity, and lower appropriateness for medical applications. Experiments confirm precision and consistency of Taguchi optimization, reinforcing scientific rigor and dependability of results. This study offers innovative perspectives on the adjustable design of electro spun nanofibers, paving the door for the creation of sophisticated wound dressings enhance expedite healing and tissue integration. Optimized PEO/PLA nanofibers possess capacity to transform wound care providing cost-efficient and clinically feasible alternative of accelerating shortening treatment durations, optimizing global healthcare outcomes and patient recovery.</p>

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Multi-parameter optimization and ann prediction of electro spun PEO/PLA nanofibers for hydrophilic and mechanically robust wound dressings

  • 期刊论文

  • 发表日期：

    2026年4月22日

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  • Sathish Kumar Shanmugam,
  • Aman Kumar,
  • Anutonk,
  • A. John Pradeep Ebenezer,
  • SK Hasane Ahammad,
  • C. Jayabalan

摘要

The amalgamation of poly (lactic acid) (PLA) with (PEO) poly (ethylene oxide) improves hydrophilicity and tensile strength of nanofibers, rendering appropriate for biomedical uses such as dressings. This research investigates influence of electrospinning parameters—flow rate, needle-to-collector distance and applied voltage—on the properties of PEO/PLA nanofibers, optimizing through Taguchi methodology to improve their surface and mechanical characteristics for clinical applications. Due to significant expenses and duration involved in doing comprehensive experimental tests, ANN- model were created to anticipate test results efficiently, hence expediting the discovery of design. ANOVA indicates flow rate is primary factor of fiber diameter. Ideal electrospinning setup produces nanofibers with average diameter of 132.26 ± 11.23 nm. Fibers display remarkable flexibility, tensile strength, and contact angle of 37°, indicating enhanced hydrophilicity that facilitates proliferation and cell adhesion—crucial elements at advancing wound healing. The optimized scaffold substantially surpasses alternative, 1.1 ml/h flow rate, 22 kV applied voltage, and 18 cm needle-to-collector distance, exhibit larger diameters, decreased hydrophilicity, and lower appropriateness for medical applications. Experiments confirm precision and consistency of Taguchi optimization, reinforcing scientific rigor and dependability of results. This study offers innovative perspectives on the adjustable design of electro spun nanofibers, paving the door for the creation of sophisticated wound dressings enhance expedite healing and tissue integration. Optimized PEO/PLA nanofibers possess capacity to transform wound care providing cost-efficient and clinically feasible alternative of accelerating shortening treatment durations, optimizing global healthcare outcomes and patient recovery.