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<p>In this work, the ability of copper oxide (CuO) nanoparticles produced with the help of a green route with the help of <i>Gymnema sylvestre</i> to degrade the fifth-generation antibiotic Ceftaroline fosamil in the pharmaceutical wastewater is evaluated. The characterization of the synthesized CuO nanoparticles was conducted by means of UV-Visible events, Fourier Transform Infrared (FTIR) and morphological analysis through Field Emission Scanning Electron Microscopy (FE-SEM). The presence of phytochemical constituents that result in the reduction and stabilization in the formation of the nanoparticles was established by the use of Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The batch degradation experiments were conducted to investigate the effect of initial concentration of antibiotics, dose of nanoparticles, duration of the reaction, ionic strength, and pH on the removal performance. Photocatalytic behaviour was determined in the sunlight and dark conditions. There was a significant decline of antibiotic activity as there was a reduction in the inhibition zone of 28.2&#xa0;mm (control) to 4.0&#xa0;mm after 120&#xa0;min of sunlight exposure, and 10.8&#xa0;mm in darkness, which was a sign of increased photocatalytic activity under irradiation. The residual antibiotic activity was also confirmed by the antibacterial assays of Escherichia coli in terms of the zone of inhibition technique. The optimal range of nanoparticles dosage, pH and reaction time gave maximum degradation. The results indicate that biosynthesized CuO nanoparticles represent a viable and greener approach of reducing pharmaceutical contaminants and reducing the risks of environmental hazards in relation to antibiotic resistance.</p>

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Effect of Gymnema sylvestre biosynthesized CuO nanoparticles for degradation of fifth generation Ceftaroline fosamil antibiotic from pharmaceutical wastes

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Sathiya Selvaraj,
  • Durairaj Sankaran,
  • Balakrishnan Pappan

摘要

In this work, the ability of copper oxide (CuO) nanoparticles produced with the help of a green route with the help of Gymnema sylvestre to degrade the fifth-generation antibiotic Ceftaroline fosamil in the pharmaceutical wastewater is evaluated. The characterization of the synthesized CuO nanoparticles was conducted by means of UV-Visible events, Fourier Transform Infrared (FTIR) and morphological analysis through Field Emission Scanning Electron Microscopy (FE-SEM). The presence of phytochemical constituents that result in the reduction and stabilization in the formation of the nanoparticles was established by the use of Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The batch degradation experiments were conducted to investigate the effect of initial concentration of antibiotics, dose of nanoparticles, duration of the reaction, ionic strength, and pH on the removal performance. Photocatalytic behaviour was determined in the sunlight and dark conditions. There was a significant decline of antibiotic activity as there was a reduction in the inhibition zone of 28.2 mm (control) to 4.0 mm after 120 min of sunlight exposure, and 10.8 mm in darkness, which was a sign of increased photocatalytic activity under irradiation. The residual antibiotic activity was also confirmed by the antibacterial assays of Escherichia coli in terms of the zone of inhibition technique. The optimal range of nanoparticles dosage, pH and reaction time gave maximum degradation. The results indicate that biosynthesized CuO nanoparticles represent a viable and greener approach of reducing pharmaceutical contaminants and reducing the risks of environmental hazards in relation to antibiotic resistance.