<p>In modern sciences, Nanoparticles become a vital aspect of discussion and learn, of which silver nanoparticles are the most critical due to their characteristic physicochemical and biological nature. The biosynthesis of AgNPs using plants is one of the most significant preferable biological method biosynthesized using plant materials because they contain small-molecule metabolites such as phenolics and flavonoids that act as reducing as well as capping and stabilize agents, and It quickly produces nanoparticles with a controlled shape and size. This paper also explained all the critical parameters essential that influence synthesize conditions as pH, temperature, and time modulation, and it also addressed other characterizations used to confirm the crystalline structure and surface chemistry mechanism of AgNPs with the possible stability and shape. In conclusion, AgNPs have drawn more interest because they are used in various sectors: in the area of biomedicine because plant-mediated AgNPs have antibacterial, anticancer, drug delivery and anti-inflammatory capabilities and this paper presents how plant-mediated AgNPs can be considered as multi-dimensioned eco-friendly and nontoxic nanomaterial that offer innovative approaches to address biological, environmental, agricultural, food safety and industrial issues.</p>