pH dependence of perturbed angular correlation in DOTA chelated $^{111}$In measured with ring-shape gamma-ray detectors

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2024年2月14日

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Kenji Shimazoe,
Kim Donghwan,
Tomoko Mineo,
Takeshi Sato,
Seiichi Ohta,
Toshifumi Tatsumi,
Akira Sugiyama,
Kenzo Yamatsugu,
Sachiyo Nomura,
Ryohei Terabayashi,
Hideki Tomita,
Tetsu Sonoda,
Yudai Shigekawa,
Takuya Yokokita,
Mizuki Uenomachi

摘要

The conventional nuclear medical imaging, such as PET and SPECT, visualizes the accumulation of radioisotopes in the human body and has been widely used for diagnosis of cancer and other diseases. Perturbed angular correlation is a powerful sensing tool detecting local electro-magnetic environment and has been used for chemical analysis or nuclear physics research. The use of perturbed angular correlation in nuclear medicine is recently proposed and pH sensing capability with liquid $^{111}$ $^{111}$ In has been confirmed. In more practical applications, DOTA based radioisotope labeled drug delivery is common in nuclear medicine. This study aims to characterize the pH dependance of perturbed angular correlation in Psyche-DOTA chelated $^{111}$ $^{111}$ In with the custom ring-shape gamma-ray detectors. The observed transition in anisotropy of cascade gamma-ray emission can contribute to the detection of a specific phenomenon changing pH inside the human body.

pH dependence of perturbed angular correlation in DOTA chelated \(^{111}\)In measured with ring-shape gamma-ray detectors

摘要