<p>The implementation of Health Information Systems (HIS) has become a critical component of healthcare digital transformation, enabling improved data management, clinical decision-making, and healthcare delivery. However, the growing body of research in this field remains fragmented across multiple disciplines and technological domains. This study aims to map research trends on HIS implementation and provide a structured overview of the evolution, key contributors, and thematic developments in the field. A bibliometric analysis was conducted using the Scopus database, based on a TITLE-ABS-KEY search query covering the period 2015–2025. After applying inclusion criteria and data cleaning procedures, a dataset of 4,793 publications was analyzed using VOSviewer and Biblioshiny to identify publication trends, leading contributors, and keyword co-occurrence patterns. The results reveal a sustained growth in research activity, with contributions concentrated in countries such as the United States, China, and Germany, alongside increasing participation from emerging economies. Keyword analysis identifies six major research themes, including public health information systems, clinical applications, interoperability, digital health services, artificial intelligence, and implementation challenges. The overlay visualization further highlights a temporal shift from foundational system development and interoperability toward data-driven and intelligent healthcare systems. Overall, the findings indicate that HIS research is evolving toward integrated, intelligent, and data-driven infrastructures while continuing to address implementation challenges, particularly in resource-constrained settings. This study provides a structured understanding of the research landscape and offers insights to support future research and the effective implementation of HIS.</p>