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<p>Oral mucosal ulcerations are prevalent and debilitating conditions that impair functions such as mastication and speaking. <i>Ocimum basilicum</i> (Basil) is a plant rich in anti-inflammatory and antioxidant phytochemicals that promote healing. Solid lipid nanoparticles (SLNs) serve as drug delivery system to enhance the bioavailability and absorption of encapsulated herbal compounds. This work aimed to assess the healing efficiency of <i>Ocimum basilicum</i> solid lipid nanoparticles (B-SLNs) oral gel compared to commercial Oracure® gel on induced buccal ulcers in rats. Buccal ulcers were induced in fifty-four adult male rats using 50% acetic acid for 60 s. The rats were divided into three groups: one untreated (positive control) and two experimental groups treated with B-SLNs gel or Oracure® gel (0.5mg, three times) daily. Six animals from each group were euthanized at 3, 5, and 7 days. Buccal tissues were excised and analyzed via histological and histomorphometric examinations, as well as immunofluorescent localization of vascular endothelial growth factor (VEGF). Tissue levels of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) were measured using enzyme-linked immunosorbent assays (ELISA). The B-SLNs gel significantly reduced ulcer size and increased VEGF, IL-10, SOD, and GSH levels versus positive control (<i>p</i> &lt; 0.001). The treated groups had lower TNF-α and MDA levels than the positive control (<i>p</i> &lt; 0.001), while B-SLNs had notably lower levels than Oracure group. B-SLNs oral gel showed greater potential for treating chemically induced buccal ulcers in rats compared to commercial Oracure® gel.</p>

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Evaluation of the healing efficiency of mucoadhesive Ocimum basilicum solid lipid nano particles oral gel versus Oracure® gel in the treatment of induced buccal ulcer in rats

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Nesma Abdel Moneim,
  • Sanaa Elzoghby,
  • Rehab Abdelmonem,
  • Asmaa Serry Elgamal,
  • Sana Mostafa

摘要

Oral mucosal ulcerations are prevalent and debilitating conditions that impair functions such as mastication and speaking. Ocimum basilicum (Basil) is a plant rich in anti-inflammatory and antioxidant phytochemicals that promote healing. Solid lipid nanoparticles (SLNs) serve as drug delivery system to enhance the bioavailability and absorption of encapsulated herbal compounds. This work aimed to assess the healing efficiency of Ocimum basilicum solid lipid nanoparticles (B-SLNs) oral gel compared to commercial Oracure® gel on induced buccal ulcers in rats. Buccal ulcers were induced in fifty-four adult male rats using 50% acetic acid for 60 s. The rats were divided into three groups: one untreated (positive control) and two experimental groups treated with B-SLNs gel or Oracure® gel (0.5mg, three times) daily. Six animals from each group were euthanized at 3, 5, and 7 days. Buccal tissues were excised and analyzed via histological and histomorphometric examinations, as well as immunofluorescent localization of vascular endothelial growth factor (VEGF). Tissue levels of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) were measured using enzyme-linked immunosorbent assays (ELISA). The B-SLNs gel significantly reduced ulcer size and increased VEGF, IL-10, SOD, and GSH levels versus positive control (p < 0.001). The treated groups had lower TNF-α and MDA levels than the positive control (p < 0.001), while B-SLNs had notably lower levels than Oracure group. B-SLNs oral gel showed greater potential for treating chemically induced buccal ulcers in rats compared to commercial Oracure® gel.