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<p>Autism spectrum disorder (ASD) has some comorbidities like seizure. Maternal separation (MS) provoke ASD-related behaviors. There are discrepancies regarding effect of MS on seizure susceptibility. Structural alterations in the pyramidal layer of the hippocampus as well as MeCP2 and HMGB1 are implicated in the physiopathology of ASD and seizure. This study aimed to determine the possible alterations in the expression of MeCP2 and HMGB1 mRNA in the hippocampus and PFC as well as histopathological amendments in the hippocampus in seizures susceptibility subsequent of MS-induced ASD-related phenotype in male mice. 32 male mice divided in to 4 groups including control, pentylenetetrazol (PTZ)—induced seizure, MS and MS + PTZ. Seizure threshold and behaviors related to ASD were performed. Diameter, neuronal density, and percent of dark neurons in the CA1 and CA3 areas of the hippocampus in addition to expression of MeCP2 and HMGB1 mRNA in the hippocampus and prefrontal cortex (PFC) were assessed. Finding: MS decreased seizure threshold. MS associated with ASD- like behaviors. MS and seizure potentiated negative effects of each other on the structural amendments in the CA1 and CA3 areas. The expression of MeCP2 mRNA decreased in the PFC and hippocampus of MS mice, while any difference did observe in the PTZ and MS + PTZ groups. HMGB1 mRNA expression showed any difference among groups. We conclude that, partially, structural changes in the hippocampus may has role in the bilateral effect of MS and PTZ on comorbid autistic-like behaviors and susceptibility to seizure in mice.</p>

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Hippocampal modifications partially mediates the boosted effects of seizure induction on ASD-related behaviors in maternally separated mice, while HMGB1 and MeCP2 mRNA levels remained unchanged

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Amir Hossein Mousavi,
  • Shima Balali-Dehkordi,
  • Mohammad Rahimi-Madiseh,
  • Elham Zarean,
  • Hossein Amini-Khoei

摘要

Autism spectrum disorder (ASD) has some comorbidities like seizure. Maternal separation (MS) provoke ASD-related behaviors. There are discrepancies regarding effect of MS on seizure susceptibility. Structural alterations in the pyramidal layer of the hippocampus as well as MeCP2 and HMGB1 are implicated in the physiopathology of ASD and seizure. This study aimed to determine the possible alterations in the expression of MeCP2 and HMGB1 mRNA in the hippocampus and PFC as well as histopathological amendments in the hippocampus in seizures susceptibility subsequent of MS-induced ASD-related phenotype in male mice. 32 male mice divided in to 4 groups including control, pentylenetetrazol (PTZ)—induced seizure, MS and MS + PTZ. Seizure threshold and behaviors related to ASD were performed. Diameter, neuronal density, and percent of dark neurons in the CA1 and CA3 areas of the hippocampus in addition to expression of MeCP2 and HMGB1 mRNA in the hippocampus and prefrontal cortex (PFC) were assessed. Finding: MS decreased seizure threshold. MS associated with ASD- like behaviors. MS and seizure potentiated negative effects of each other on the structural amendments in the CA1 and CA3 areas. The expression of MeCP2 mRNA decreased in the PFC and hippocampus of MS mice, while any difference did observe in the PTZ and MS + PTZ groups. HMGB1 mRNA expression showed any difference among groups. We conclude that, partially, structural changes in the hippocampus may has role in the bilateral effect of MS and PTZ on comorbid autistic-like behaviors and susceptibility to seizure in mice.