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<p>Diabetic Retinopathy is a microvascular complication associated with diabetes mellitus. Vasant Kusumakar Rasa (VKR) an Ayurvedic herbo-mineral formulation may offer a promising approach for diabetic complication such as retinopathy. The study aimed to assess the efficacy of VKR in a rat model of type 2 diabetic retinopathy. Type 2 diabetes was induced in <i>Sprague Dawley</i> rats by feeding high fat diet (HFD) for 8 weeks followed by single injection of streptozotocin (35&#xa0;mg/kg <i>i.p.</i>). High fat diet was continued throughout the study duration. Following induction of diabetes, the rats received oral dosing of VKR at doses of 28 and 56&#xa0;mg/kg. At the end of 16 weeks treatment, various biochemical and oxidative stress parameters were evaluated. Additionally, electroretinogram were recorded for experimental animals to examine retinal function. Expression of MMP-2 and VEGF was studied in eye. The results indicated that VKR treated animals significantly modulated different glycaemic parameters and lipid parameters in comparison to the diabetic control group. VKR-treated group at dose 56&#xa0;mg/kg exhibited reduced levels of aldose reductase, sorbitol dehydrogenase and lactate dehydrogenase. In electroretinography, both VKR doses demonstrated the capacity to mitigate changes in the amplitude and latency of ‘a’ and ‘b’ waves relative to the diabetic control group. Furthermore, an increase in antioxidant enzyme level was observed in diabetic animals following VKR treatment. The expression levels of MMP-2 and VEGF was also reduced in VKR-treated diabetic group. Overall, the study results indicate that Vasant Kusumakar Rasa may be effective in the management of type 2 diabetic retinopathy.</p>

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Vasant Kusumakar Rasa reduces neovascularisation, oxidative stress, inflammation and improves retinal function in diabetic rats

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Alok D. Singh,
  • Mukesh B. Chawda,
  • Yogesh A. Kulkarni

摘要

Diabetic Retinopathy is a microvascular complication associated with diabetes mellitus. Vasant Kusumakar Rasa (VKR) an Ayurvedic herbo-mineral formulation may offer a promising approach for diabetic complication such as retinopathy. The study aimed to assess the efficacy of VKR in a rat model of type 2 diabetic retinopathy. Type 2 diabetes was induced in Sprague Dawley rats by feeding high fat diet (HFD) for 8 weeks followed by single injection of streptozotocin (35 mg/kg i.p.). High fat diet was continued throughout the study duration. Following induction of diabetes, the rats received oral dosing of VKR at doses of 28 and 56 mg/kg. At the end of 16 weeks treatment, various biochemical and oxidative stress parameters were evaluated. Additionally, electroretinogram were recorded for experimental animals to examine retinal function. Expression of MMP-2 and VEGF was studied in eye. The results indicated that VKR treated animals significantly modulated different glycaemic parameters and lipid parameters in comparison to the diabetic control group. VKR-treated group at dose 56 mg/kg exhibited reduced levels of aldose reductase, sorbitol dehydrogenase and lactate dehydrogenase. In electroretinography, both VKR doses demonstrated the capacity to mitigate changes in the amplitude and latency of ‘a’ and ‘b’ waves relative to the diabetic control group. Furthermore, an increase in antioxidant enzyme level was observed in diabetic animals following VKR treatment. The expression levels of MMP-2 and VEGF was also reduced in VKR-treated diabetic group. Overall, the study results indicate that Vasant Kusumakar Rasa may be effective in the management of type 2 diabetic retinopathy.