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Introduction <p>Lead (Pb) remains a pervasive environmental contaminant with well-documented toxic effects on multiple organ systems, including the nervous and hematopoietic systems. Polydatin (PD; piceid), a natural stilbene glycoside found in <i>Polygonum cuspidatum</i> and other edible plants, exhibits potent antioxidant and anti-inflammatory properties.</p> Aim <p>This study investigated the protective effects of polydatin against lead-induced hematological disturbances, neuroinflammation, and hippocampal structural alterations in Wistar rats.</p> Methods <p>Experimental lead exposure was established in rats, followed by oral administration of polydatin at graded doses or a reference chelator. Hematological indices, pro-inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α), and hippocampal histopathological and immunohistochemical markers were evaluated in blood and brain tissues.</p> Results <p>Polydatin treatment significantly improved altered hematological parameters and markedly reduced pro-inflammatory cytokine levels in both serum and brain tissues of lead-exposed rats. Histological examination revealed attenuation of lead-induced neuronal damage, while immunohistochemical analyses demonstrated reduced glial fibrillary acidic protein (GFAP) expression and enhanced brain-derived neurotrophic factor (BDNF) immunoreactivity, indicating mitigation of neuroinflammatory and neurodegenerative changes.</p> Conclusion <p>Polydatin effectively alleviates lead-induced hematological dysfunction, neuroinflammation, and hippocampal damage, primarily through its anti-inflammatory and neuroprotective properties.</p>

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Polydatin attenuates lead-induced hematotoxicity and neuroinflammation: insights from hematological, cytokine, and histopathological analyses in Wistar rats

  • 期刊论文

  • 发表日期：

    2026年4月10日

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  • Salisu Muhammad Highab,
  • Abdulhakim Abubakar,
  • Sanusi Muhammad Salisu,
  • Rabiu Nuhu Danraka,
  • Nawiyyu Musa,
  • Mohammed Garba Magaji,
  • Dalhatu Mukhtar Shehu,
  • Jamilu Ya’u

摘要

Introduction

Lead (Pb) remains a pervasive environmental contaminant with well-documented toxic effects on multiple organ systems, including the nervous and hematopoietic systems. Polydatin (PD; piceid), a natural stilbene glycoside found in Polygonum cuspidatum and other edible plants, exhibits potent antioxidant and anti-inflammatory properties.

Aim

This study investigated the protective effects of polydatin against lead-induced hematological disturbances, neuroinflammation, and hippocampal structural alterations in Wistar rats.

Methods

Experimental lead exposure was established in rats, followed by oral administration of polydatin at graded doses or a reference chelator. Hematological indices, pro-inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α), and hippocampal histopathological and immunohistochemical markers were evaluated in blood and brain tissues.

Results

Polydatin treatment significantly improved altered hematological parameters and markedly reduced pro-inflammatory cytokine levels in both serum and brain tissues of lead-exposed rats. Histological examination revealed attenuation of lead-induced neuronal damage, while immunohistochemical analyses demonstrated reduced glial fibrillary acidic protein (GFAP) expression and enhanced brain-derived neurotrophic factor (BDNF) immunoreactivity, indicating mitigation of neuroinflammatory and neurodegenerative changes.

Conclusion

Polydatin effectively alleviates lead-induced hematological dysfunction, neuroinflammation, and hippocampal damage, primarily through its anti-inflammatory and neuroprotective properties.