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<p>Irradiation (IR)-induced intestinal injury is a common complication in abdominal and pelvic radiotherapy in neoplastic diseases. It has been found that olanzapine (OLZ), an atypical antipsychotic medication, exhibits antioxidant and anti-inflammatory, and anti-apoptotic properties at low doses. The present study aimed to investigate the radioprotective effects of OLZ against acute intestinal injury of irradiation. In this experimental study, sixty adult male BALB/c mice (30–35 g) were split into six groups (10/group): Control, 10 mg/kg of OLZ (OLZ 10), 20 mg/kg of OLZ (OLZ 20) for 10 consecutive days, 6 Gy total body X-irradiation on the 8th day, OLZ 10 + IR, and OLZ 20 + IR. On the 11th day of the study, blood and small intestine samples were prepared for biochemical, histological, and immunohistochemistry assays. The study results indicated that irradiation decreased the survival rate, increased the weight, and activated the expression of Caspase-3 and NF-κB in the intestinal tissues. An increase in MDA levels and a decrease in GSH levels were observed in irradiated mice. OLZ was able to prolong the average survival rate of mice after IR, improve intestinal morphology, and reduce oxidative stress, apoptosis, and inflammation. We hypothesize that OLZ, with its increased survival rate, mitigates radiation-induced intestinal injury by suppressing oxidative stress, inflammation, and apoptosis, thereby protecting against epithelial damage and preventing villi and crypt shortening in the intestinal tract.</p>

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The radioprotective effect of olanzapine on intestinal injury via modulation of oxidative stress, NF-κB, and caspase-3 expression

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Ali Mirmahdi,
  • Seyed Jalal Hosseinimehr,
  • Mehryar Zargari,
  • Mansooreh Mirzaei,
  • Abbasali Karimpour Malekshah,
  • Fereshteh Talebpour Amiri

摘要

Irradiation (IR)-induced intestinal injury is a common complication in abdominal and pelvic radiotherapy in neoplastic diseases. It has been found that olanzapine (OLZ), an atypical antipsychotic medication, exhibits antioxidant and anti-inflammatory, and anti-apoptotic properties at low doses. The present study aimed to investigate the radioprotective effects of OLZ against acute intestinal injury of irradiation. In this experimental study, sixty adult male BALB/c mice (30–35 g) were split into six groups (10/group): Control, 10 mg/kg of OLZ (OLZ 10), 20 mg/kg of OLZ (OLZ 20) for 10 consecutive days, 6 Gy total body X-irradiation on the 8th day, OLZ 10 + IR, and OLZ 20 + IR. On the 11th day of the study, blood and small intestine samples were prepared for biochemical, histological, and immunohistochemistry assays. The study results indicated that irradiation decreased the survival rate, increased the weight, and activated the expression of Caspase-3 and NF-κB in the intestinal tissues. An increase in MDA levels and a decrease in GSH levels were observed in irradiated mice. OLZ was able to prolong the average survival rate of mice after IR, improve intestinal morphology, and reduce oxidative stress, apoptosis, and inflammation. We hypothesize that OLZ, with its increased survival rate, mitigates radiation-induced intestinal injury by suppressing oxidative stress, inflammation, and apoptosis, thereby protecting against epithelial damage and preventing villi and crypt shortening in the intestinal tract.