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<p><i>Pimpinella brachycarpa</i> has been used in food and traditional herbal medicine for its anti-inflammatory and antimicrobial properties. This study evaluated the therapeutic potential of <i>P. brachycarpa</i> extract (PBE) in a rat model of ligature-induced periodontitis and identified its active compounds, such as green tea catechin (GTC), chlorogenic acid (CGA), and their combination (MIX). Seven-week-old rats received PBE (150–300&#xa0;mg/kg/day) for 14 days post-ligation to induce periodontitis. Outcomes were assessed using gross morphology, histology, TRAP staining, and immunohistochemistry. UPLC revealed CGA as a major constituent in PBE. PBE significantly reduced alveolar bone loss and inflammatory responses compared to the vehicle-treated ligature-induced periodontitis group (LIG), with effects comparable to or exceeding those of ISD (<i>Zea mays</i> L. extract and Magnolia cortex extract-containing herbal formulaas a reference drug), GTC, CGA, and MIX. TRAP and IHC analyses indicated suppression of osteoclast activity and decreased expression of CD45, IL-1β, and TNF-α. These findings suggest that PBE mitigates periodontitis via modulation of osteoclastogenesis and immune responses. Given its efficacy and bioactive profile, PBE may serve as a promising candidate for the development of natural therapeutics against periodontal disease.</p>

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Anti-Inflammatory and bone-protective effects of Pimpinella brachycarpa extract in a rat periodontitis model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月10日

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  • Su-Bin Park,
  • Yun Mi Lee,
  • Hwa Young Yu,
  • Jae-Eun Jung,
  • Eunjung Son,
  • Junghyun Kim

摘要

Pimpinella brachycarpa has been used in food and traditional herbal medicine for its anti-inflammatory and antimicrobial properties. This study evaluated the therapeutic potential of P. brachycarpa extract (PBE) in a rat model of ligature-induced periodontitis and identified its active compounds, such as green tea catechin (GTC), chlorogenic acid (CGA), and their combination (MIX). Seven-week-old rats received PBE (150–300 mg/kg/day) for 14 days post-ligation to induce periodontitis. Outcomes were assessed using gross morphology, histology, TRAP staining, and immunohistochemistry. UPLC revealed CGA as a major constituent in PBE. PBE significantly reduced alveolar bone loss and inflammatory responses compared to the vehicle-treated ligature-induced periodontitis group (LIG), with effects comparable to or exceeding those of ISD (Zea mays L. extract and Magnolia cortex extract-containing herbal formulaas a reference drug), GTC, CGA, and MIX. TRAP and IHC analyses indicated suppression of osteoclast activity and decreased expression of CD45, IL-1β, and TNF-α. These findings suggest that PBE mitigates periodontitis via modulation of osteoclastogenesis and immune responses. Given its efficacy and bioactive profile, PBE may serve as a promising candidate for the development of natural therapeutics against periodontal disease.