Scholarlink

<p>Skin aging is a prominent manifestation of human aging, largely driven by oxidative stress and inflammation. D-limonene, a natural monoterpene, possesses strong antioxidant and anti-inflammatory properties that may help counteract these effects. This study aimed to explore the anti-aging and skin-rejuvenating potential of D-limonene in a mouse model of D-galactose-induced skin aging. 60 male mice were divided into 6 groups (n = 10). Group I served as the control. Group II received D-galactose (500&#xa0;mg/kg) for 42&#xa0;days to induce aging. Groups III and IV received vitamin C (100&#xa0;mg/kg) either concurrently with D-galactose or after aging induction, respectively. Groups V and VI received D-limonene (100&#xa0;mg/kg) either simultaneously with D-galactose or after induction. This design allowed comparison of protective versus therapeutic effects. Both concurrent and post-treatment with D-limonene substantially decreased pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and the oxidative stress marker MDA, while enhancing antioxidant components (SOD and GPx) and promoting the synthesis of collagen types I and III. Additionally, it improved skin thickness and histomorphological scores, restoring normal skin architecture. D-limonene exerts potent anti-aging and skin-rejuvenating effects by modulating oxidation and inflammatory markers, suggesting its potential as a preventive and curative anti-aging agent.</p> Graphical abstract

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

D-limonene attenuates D-galactose-induced skin aging mouse model

  • 期刊论文

  • 发表日期：

    2025年11月4日

查看全文
  • Rana Jawad Hasan AlBairmani,
  • Elaf Mahmood Shihab,
  • Hayder Ridha-Salman,
  • Haitham Mahmood Kadhim,
  • Rawaa M. Mohammed,
  • Samer Salim Shahooth,
  • Mayssaa E. Abdalah,
  • Zinah Essam Hameed,
  • Salim K. Hajwal,
  • Omar Waleed Albasri,
  • Lina Sami Adham,
  • Yasser Kadhim Al-Zwaini

摘要

Skin aging is a prominent manifestation of human aging, largely driven by oxidative stress and inflammation. D-limonene, a natural monoterpene, possesses strong antioxidant and anti-inflammatory properties that may help counteract these effects. This study aimed to explore the anti-aging and skin-rejuvenating potential of D-limonene in a mouse model of D-galactose-induced skin aging. 60 male mice were divided into 6 groups (n = 10). Group I served as the control. Group II received D-galactose (500 mg/kg) for 42 days to induce aging. Groups III and IV received vitamin C (100 mg/kg) either concurrently with D-galactose or after aging induction, respectively. Groups V and VI received D-limonene (100 mg/kg) either simultaneously with D-galactose or after induction. This design allowed comparison of protective versus therapeutic effects. Both concurrent and post-treatment with D-limonene substantially decreased pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and the oxidative stress marker MDA, while enhancing antioxidant components (SOD and GPx) and promoting the synthesis of collagen types I and III. Additionally, it improved skin thickness and histomorphological scores, restoring normal skin architecture. D-limonene exerts potent anti-aging and skin-rejuvenating effects by modulating oxidation and inflammatory markers, suggesting its potential as a preventive and curative anti-aging agent.

Graphical abstract