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<p>A gastric ulcer is a disease that occurs as a result of erosion of the epithelial lining of the gastric mucosa. In the management of this disease, most of the drugs in use have some shortcomings. In order to overcome these shortcomings, β, Ɛ-carotene-3,3′-diol, which is a non-provitamin type of carotenoid with antioxidant and anti-inflammatory properties, seems to be a better remedy in the management of this deadly disease. Forty-two adult male Wistar rats (7 weeks old, 160–165&#xa0;g) were used for this study. The rats were divided into six groups of seven rats each. (Group A – control, Group B – negative control, Group C was treated with 20&#xa0;mg/kg b.w. of omeprazole (OMZ), while D, E and F were treated with 20, 40 and 80&#xa0;mg/kg b.w. of ß, Ɛ-carotene-3,3′-diol, respectively, 12 hourly for 14 days following indomethacin-induced gastric ulcers. All rats were fasted for 24&#xa0;h before gastric ulcer induction. After the last day of administration, rats were fasted for 24&#xa0;h for gastric emptying and later sacrificed using chloroform as anesthesia. The stomach of the rats was harvested and opened along the lesser curvature and subsequently processed for histological and histochemical assays. The non-treated rats showed a significant decrease in collagen and mucus-secreting cells when compared to the control and treated groups at <i>p</i> &lt; 0.05. ß-Ɛ-Carotene-3,3′-diol at the highest dose (80&#xa0;mg/kg) seems to have a better remediation when compared with the OMZ-treated group.</p>

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Microanatomical effects of ß, ɛ-carotene-3,3′-diol on indomethacin induced gastric ulcer in male wistar rats

  • 期刊论文

  • 发表日期：

    2025年11月14日

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  • Victory Opeyemi Adekunle,
  • David Adesanya Ofusori

摘要

A gastric ulcer is a disease that occurs as a result of erosion of the epithelial lining of the gastric mucosa. In the management of this disease, most of the drugs in use have some shortcomings. In order to overcome these shortcomings, β, Ɛ-carotene-3,3′-diol, which is a non-provitamin type of carotenoid with antioxidant and anti-inflammatory properties, seems to be a better remedy in the management of this deadly disease. Forty-two adult male Wistar rats (7 weeks old, 160–165 g) were used for this study. The rats were divided into six groups of seven rats each. (Group A – control, Group B – negative control, Group C was treated with 20 mg/kg b.w. of omeprazole (OMZ), while D, E and F were treated with 20, 40 and 80 mg/kg b.w. of ß, Ɛ-carotene-3,3′-diol, respectively, 12 hourly for 14 days following indomethacin-induced gastric ulcers. All rats were fasted for 24 h before gastric ulcer induction. After the last day of administration, rats were fasted for 24 h for gastric emptying and later sacrificed using chloroform as anesthesia. The stomach of the rats was harvested and opened along the lesser curvature and subsequently processed for histological and histochemical assays. The non-treated rats showed a significant decrease in collagen and mucus-secreting cells when compared to the control and treated groups at p < 0.05. ß-Ɛ-Carotene-3,3′-diol at the highest dose (80 mg/kg) seems to have a better remediation when compared with the OMZ-treated group.