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<p>Sepsis is the primary cause of mortality after infection and is considered a global health issue. This study aimed to investigate whether quercetin may have any potential nephroprotective effects during renal injury induced by sepsis. 40 male albino Swiss mice were divided into 4 groups of 10 mice each. Normal control groups include mice that clearly exhibit good health. The CLP group included mice that underwent cecal ligation and puncture (CLP) surgery but received no treatment. Dimethyl sulfoxide (DMSO) group administered DMSO as a vehicle. The quercetin group was administered quercetin 10 mg/kg/day intraperitoneally for 5 consecutive days. A significant (<i>p</i> &lt; 0.05) reduction in the renal levels of Neutrophil gelatinase-associated lipocalin (NGAL) was observed in the quercetin group compared to the CLP group. A significant (<i>p</i> &lt; 0.05) reduction in the serum levels of inflammatory cytokines (TNF-α, IL-6, and IL-1β) was observed in the quercetin group compared to the CLP group. Additionally, the quercetin group exhibited a significant (<i>p</i> &lt; 0.05) increase in renal SOD activity and a reduction in MDA levels in comparison to the CLP group. Histologically, all mice in the CLP group exhibited a significant (<i>p</i> &lt; 0.05) renal tissue injury, whereas the quercetin group exhibited a significant (<i>p</i> &lt; 0.05) reduction in renal tissue injury. The quercetin exhibited an anti-inflammatory effect by reducing serum levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as an antioxidant effect by decreasing renal levels of MDA and increasing the renal activity of SOD.</p>

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Quercetin mitigates sepsis-induced renal injury via inhibiting inflammatory and oxidative pathways in mice

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • Abdulla Kadhim Raheem,
  • Ahmed Rahmah Abu-Raghif,
  • Alaa Hamza Abbas,
  • Hayder Ridha-Salman,
  • Enass Najem Oubaid

摘要

Sepsis is the primary cause of mortality after infection and is considered a global health issue. This study aimed to investigate whether quercetin may have any potential nephroprotective effects during renal injury induced by sepsis. 40 male albino Swiss mice were divided into 4 groups of 10 mice each. Normal control groups include mice that clearly exhibit good health. The CLP group included mice that underwent cecal ligation and puncture (CLP) surgery but received no treatment. Dimethyl sulfoxide (DMSO) group administered DMSO as a vehicle. The quercetin group was administered quercetin 10 mg/kg/day intraperitoneally for 5 consecutive days. A significant (p < 0.05) reduction in the renal levels of Neutrophil gelatinase-associated lipocalin (NGAL) was observed in the quercetin group compared to the CLP group. A significant (p < 0.05) reduction in the serum levels of inflammatory cytokines (TNF-α, IL-6, and IL-1β) was observed in the quercetin group compared to the CLP group. Additionally, the quercetin group exhibited a significant (p < 0.05) increase in renal SOD activity and a reduction in MDA levels in comparison to the CLP group. Histologically, all mice in the CLP group exhibited a significant (p < 0.05) renal tissue injury, whereas the quercetin group exhibited a significant (p < 0.05) reduction in renal tissue injury. The quercetin exhibited an anti-inflammatory effect by reducing serum levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as an antioxidant effect by decreasing renal levels of MDA and increasing the renal activity of SOD.