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<p><i>Laggera alata</i> (DC.) Sch.Bip. ex Oliv. (Asteraceae) is a medicinal plant that has attracted growing interest because of its ethnomedicinal relevance, diverse phytochemical constituents, and promising pharmacological activities. This review systematically examines the traditional uses, phytochemical composition, and biological potential of <i>L. alata</i>, with particular emphasis on its reported medicinal applications, isolated compounds, and experimentally validated bioactivities. In traditional medicine, plants of the Asteraceae family have long been used as both remedies and food resources with health-promoting effects, and <i>L. alata</i> represents an important example of a species with increasing therapeutic significance. A comprehensive literature search was conducted across major scientific databases, including PubMed, Springer Nature Link, Elsevier ScienceDirect, and Google Scholar, to collect and critically evaluate research related to <i>L. alata</i> and selected related species within the genus <i>Laggera</i>. The available evidence indicates that <i>L. alata</i> possesses notable pharmacological properties, including hepatoprotective, anti-inflammatory, anti-angiogenic, antiviral activity against hepatitis B virus, and mosquito larvicidal effects. Phytochemical investigations have revealed a range of bioactive constituents, particularly flavonoids, phenylpropanoids, and sesquiterpenes, which are considered the principal active components responsible for many of its biological effects. These findings provide a plausible scientific basis linking the plant’s traditional uses with its experimentally observed pharmacological mechanisms. In addition to summarizing current knowledge on its taxonomy, botanical description, geographical distribution, chemical composition, and biological activities demonstrated in both in vitro and in vivo research, this review also highlights existing gaps and the need for further phytochemical and pharmacological investigations. Overall, <i>L. alata</i> emerges as a valuable source of bioactive natural products and a promising candidate for future drug discovery, including the isolation of lead compounds and the development of novel therapeutic agents.</p>

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Exploring the ethnobotany, phytochemistry, and pharmacological promise of Laggera alata: a systematic review

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Pham Van Huyen,
  • Nguyen Thi Thu Hien,
  • Tran Thi Ngoc Hanh,
  • Nguyen Huu Huong Duyen,
  • Nguyen Huu Toan Phan,
  • Phan Nha Hoa,
  • Tran Kim Diep,
  • Quach Van Hoi,
  • Nguyen Thi Dieu Thuan

摘要

Laggera alata (DC.) Sch.Bip. ex Oliv. (Asteraceae) is a medicinal plant that has attracted growing interest because of its ethnomedicinal relevance, diverse phytochemical constituents, and promising pharmacological activities. This review systematically examines the traditional uses, phytochemical composition, and biological potential of L. alata, with particular emphasis on its reported medicinal applications, isolated compounds, and experimentally validated bioactivities. In traditional medicine, plants of the Asteraceae family have long been used as both remedies and food resources with health-promoting effects, and L. alata represents an important example of a species with increasing therapeutic significance. A comprehensive literature search was conducted across major scientific databases, including PubMed, Springer Nature Link, Elsevier ScienceDirect, and Google Scholar, to collect and critically evaluate research related to L. alata and selected related species within the genus Laggera. The available evidence indicates that L. alata possesses notable pharmacological properties, including hepatoprotective, anti-inflammatory, anti-angiogenic, antiviral activity against hepatitis B virus, and mosquito larvicidal effects. Phytochemical investigations have revealed a range of bioactive constituents, particularly flavonoids, phenylpropanoids, and sesquiterpenes, which are considered the principal active components responsible for many of its biological effects. These findings provide a plausible scientific basis linking the plant’s traditional uses with its experimentally observed pharmacological mechanisms. In addition to summarizing current knowledge on its taxonomy, botanical description, geographical distribution, chemical composition, and biological activities demonstrated in both in vitro and in vivo research, this review also highlights existing gaps and the need for further phytochemical and pharmacological investigations. Overall, L. alata emerges as a valuable source of bioactive natural products and a promising candidate for future drug discovery, including the isolation of lead compounds and the development of novel therapeutic agents.